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Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins

Galectins released by tumor cells and macrophages can bind surface glycoproteins of tumor-infiltrating lymphocytes (TILs), forming glycoprotein-galectin lattices with immunosuppressive activities. Specifically, TILs covered by galectin-3 are unable to secrete cytokines after stimulation. Treating TI...

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Detalles Bibliográficos
Autores principales:	Gordon-Alonso, Monica, Demotte, Nathalie, van der Bruggen, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2014
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091051/ https://www.ncbi.nlm.nih.gov/pubmed/25097806 http://dx.doi.org/10.4161/onci.28783

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