Activity of cytokine-induced killer cells against bone and soft tissue sarcoma

Cytokine-induced killer (CIK) cells are T lymphocytes expanded ex vivo that are endowed with MHC-independent tumoricidal activity. We have recently demonstrated, in a preclinical setting, that CIK cells are active against autologous bone and soft tissue sarcomas. In particular, CIK cells killed a pu...

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Detalles Bibliográficos
Autores principales: Sangiolo, Dario, Mesiano, Giulia, Gammaitoni, Loretta, Aglietta, Massimo, Grignani, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091097/
https://www.ncbi.nlm.nih.gov/pubmed/25050197
http://dx.doi.org/10.4161/onci.28269
Descripción
Sumario:Cytokine-induced killer (CIK) cells are T lymphocytes expanded ex vivo that are endowed with MHC-independent tumoricidal activity. We have recently demonstrated, in a preclinical setting, that CIK cells are active against autologous bone and soft tissue sarcomas. In particular, CIK cells killed a putative sarcoma stem cell population that may underlie disease relapse and chemoresistance.

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