Activity of cytokine-induced killer cells against bone and soft tissue sarcoma

Cytokine-induced killer (CIK) cells are T lymphocytes expanded ex vivo that are endowed with MHC-independent tumoricidal activity. We have recently demonstrated, in a preclinical setting, that CIK cells are active against autologous bone and soft tissue sarcomas. In particular, CIK cells killed a pu...

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Autores principales: Sangiolo, Dario, Mesiano, Giulia, Gammaitoni, Loretta, Aglietta, Massimo, Grignani, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091097/
https://www.ncbi.nlm.nih.gov/pubmed/25050197
http://dx.doi.org/10.4161/onci.28269
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author Sangiolo, Dario
Mesiano, Giulia
Gammaitoni, Loretta
Aglietta, Massimo
Grignani, Giovanni
author_facet Sangiolo, Dario
Mesiano, Giulia
Gammaitoni, Loretta
Aglietta, Massimo
Grignani, Giovanni
author_sort Sangiolo, Dario
collection PubMed
description Cytokine-induced killer (CIK) cells are T lymphocytes expanded ex vivo that are endowed with MHC-independent tumoricidal activity. We have recently demonstrated, in a preclinical setting, that CIK cells are active against autologous bone and soft tissue sarcomas. In particular, CIK cells killed a putative sarcoma stem cell population that may underlie disease relapse and chemoresistance.
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spelling pubmed-40910972015-03-17 Activity of cytokine-induced killer cells against bone and soft tissue sarcoma Sangiolo, Dario Mesiano, Giulia Gammaitoni, Loretta Aglietta, Massimo Grignani, Giovanni Oncoimmunology Author's View Cytokine-induced killer (CIK) cells are T lymphocytes expanded ex vivo that are endowed with MHC-independent tumoricidal activity. We have recently demonstrated, in a preclinical setting, that CIK cells are active against autologous bone and soft tissue sarcomas. In particular, CIK cells killed a putative sarcoma stem cell population that may underlie disease relapse and chemoresistance. Landes Bioscience 2014-03-17 /pmc/articles/PMC4091097/ /pubmed/25050197 http://dx.doi.org/10.4161/onci.28269 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Sangiolo, Dario
Mesiano, Giulia
Gammaitoni, Loretta
Aglietta, Massimo
Grignani, Giovanni
Activity of cytokine-induced killer cells against bone and soft tissue sarcoma
title Activity of cytokine-induced killer cells against bone and soft tissue sarcoma
title_full Activity of cytokine-induced killer cells against bone and soft tissue sarcoma
title_fullStr Activity of cytokine-induced killer cells against bone and soft tissue sarcoma
title_full_unstemmed Activity of cytokine-induced killer cells against bone and soft tissue sarcoma
title_short Activity of cytokine-induced killer cells against bone and soft tissue sarcoma
title_sort activity of cytokine-induced killer cells against bone and soft tissue sarcoma
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091097/
https://www.ncbi.nlm.nih.gov/pubmed/25050197
http://dx.doi.org/10.4161/onci.28269
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