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Immunogenic and tolerogenic effects of the chimeric IL-2-diphtheria toxin cytocidal agent Ontak(®) on CD25(+) cells

Ontak(®), a conjugate between IL-2 and a diphtheria toxin fragment, was recently investigated in cancer clinical trials aiming to kill CD25(+) regulatory T cells (T(regs)). We found that the activity of Ontak(®) was more complex on T(regs) and conventional T cells (T(convs)) than anticipated, includ...

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Detalles Bibliográficos
Autores principales:	Lutz, Manfred B, Baur, Andreas S, Schuler-Thurner, Beatrice, Schuler, Gerold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2014
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091105/ https://www.ncbi.nlm.nih.gov/pubmed/25050193 http://dx.doi.org/10.4161/onci.28223

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