ERBB2 overexpression suppresses stress-induced autophagy and renders ERBB2-induced mammary tumorigenesis independent of monoallelic Becn1 loss

Defective autophagy has been implicated in mammary tumorigenesis, as the gene encoding the essential autophagy regulator BECN1 is deleted in human breast cancers and Becn1(+/−) mice develop mammary hyperplasias. In agreement with a recent study, which reports concurrent allelic BECN1 loss and ERBB2...

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Detalles Bibliográficos
Autores principales: Lozy, Fred, Cai-McRae, Xiaofeng, Teplova, Irina, Price, Sandy, Reddy, Anupama, Bhanot, Gyan, Ganesan, Shridar, Vazquez, Alexei, Karantza, Vassiliki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Translational Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091153/
https://www.ncbi.nlm.nih.gov/pubmed/24492513
http://dx.doi.org/10.4161/auto.27867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091153/
https://www.ncbi.nlm.nih.gov/pubmed/24492513
http://dx.doi.org/10.4161/auto.27867

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