Cargando…
Falling asleep after a big meal: Neuronal regulation of satiety
C. elegans has become an ideal model to study genetics of appetite control and energy metabolism because of its robust conservation in molecular mechanisms underlying appetite control and in regulation of the relevant feeding behavior. Satiety behavior in worms in particular shows striking similarit...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091210/ https://www.ncbi.nlm.nih.gov/pubmed/25057453 http://dx.doi.org/10.4161/worm.27938 |
_version_ | 1782480743012761600 |
---|---|
author | Gallagher, Thomas You, Young-Jai |
author_facet | Gallagher, Thomas You, Young-Jai |
author_sort | Gallagher, Thomas |
collection | PubMed |
description | C. elegans has become an ideal model to study genetics of appetite control and energy metabolism because of its robust conservation in molecular mechanisms underlying appetite control and in regulation of the relevant feeding behavior. Satiety behavior in worms in particular shows striking similarities to that in mammals, as a worm becomes quiescent after a big meal, mimicking post-prandial sleep in mammals. Here we review our recent finding regarding the neuronal regulation of the behavior and the implication of the finding such as cyclicity of behavioral states. Based on the finding, we propose a rather speculative but intriguing view of how metabolism could link to post-prandial sleep. |
format | Online Article Text |
id | pubmed-4091210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-40912102014-07-23 Falling asleep after a big meal: Neuronal regulation of satiety Gallagher, Thomas You, Young-Jai Worm Commentary C. elegans has become an ideal model to study genetics of appetite control and energy metabolism because of its robust conservation in molecular mechanisms underlying appetite control and in regulation of the relevant feeding behavior. Satiety behavior in worms in particular shows striking similarities to that in mammals, as a worm becomes quiescent after a big meal, mimicking post-prandial sleep in mammals. Here we review our recent finding regarding the neuronal regulation of the behavior and the implication of the finding such as cyclicity of behavioral states. Based on the finding, we propose a rather speculative but intriguing view of how metabolism could link to post-prandial sleep. Landes Bioscience 2014-01-31 /pmc/articles/PMC4091210/ /pubmed/25057453 http://dx.doi.org/10.4161/worm.27938 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Commentary Gallagher, Thomas You, Young-Jai Falling asleep after a big meal: Neuronal regulation of satiety |
title | Falling asleep after a big meal: Neuronal regulation of satiety |
title_full | Falling asleep after a big meal: Neuronal regulation of satiety |
title_fullStr | Falling asleep after a big meal: Neuronal regulation of satiety |
title_full_unstemmed | Falling asleep after a big meal: Neuronal regulation of satiety |
title_short | Falling asleep after a big meal: Neuronal regulation of satiety |
title_sort | falling asleep after a big meal: neuronal regulation of satiety |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091210/ https://www.ncbi.nlm.nih.gov/pubmed/25057453 http://dx.doi.org/10.4161/worm.27938 |
work_keys_str_mv | AT gallagherthomas fallingasleepafterabigmealneuronalregulationofsatiety AT youyoungjai fallingasleepafterabigmealneuronalregulationofsatiety |