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A clinically useful approach to enhance immunological memory and antitumor immunity

Persistence of vaccine-induced immune responses, not the initial magnitude, best correlates with protective antitumor immunity. In mice, oligonucleotide aptamer-targeted siRNA inhibition of mammalian target of rapamycin (mTOR) activity in activated CD8+ T cells promotes their differentiation into fu...

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Detalles Bibliográficos
Autores principales: Berezhnoy, Alex, Rajagopalan, Anugraha, Gilboa, Eli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091317/
https://www.ncbi.nlm.nih.gov/pubmed/25057446
http://dx.doi.org/10.4161/onci.28811