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A Novel Dataset for Identifying Sex-Biased Genes in Drosophila

Phenotypic differences between males and females of sexually dimorphic species are caused in large part by differences in gene expression between the sexes, most of which occurs in the gonads. To accurately identify genes differentially expressed between males and females in Drosophila, we sequenced...

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Detalles Bibliográficos
Autores principales: VanKuren, Nicholas W., Vibranovski, Maria D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091448/
https://www.ncbi.nlm.nih.gov/pubmed/25031657
http://dx.doi.org/10.7150/jgen.7955
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author VanKuren, Nicholas W.
Vibranovski, Maria D.
author_facet VanKuren, Nicholas W.
Vibranovski, Maria D.
author_sort VanKuren, Nicholas W.
collection PubMed
description Phenotypic differences between males and females of sexually dimorphic species are caused in large part by differences in gene expression between the sexes, most of which occurs in the gonads. To accurately identify genes differentially expressed between males and females in Drosophila, we sequenced the testis and ovary transcriptomes of D. yakuba, D. pseudoobscura, and D. ananassae and used them to identify sex-biased genes in the latter two species. We highlight the increased sensitivity and improved power of sex-biased gene detection methods when using our testis/ovary data versus male and female whole body transcriptome data. We thus provide a resource specifically designed to accurately identify and characterize sex-biased genes across Drosophila. This dataset is available through NCBI GEO accession GSE52058.
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spelling pubmed-40914482014-07-16 A Novel Dataset for Identifying Sex-Biased Genes in Drosophila VanKuren, Nicholas W. Vibranovski, Maria D. J Genomics Short Research Communication Phenotypic differences between males and females of sexually dimorphic species are caused in large part by differences in gene expression between the sexes, most of which occurs in the gonads. To accurately identify genes differentially expressed between males and females in Drosophila, we sequenced the testis and ovary transcriptomes of D. yakuba, D. pseudoobscura, and D. ananassae and used them to identify sex-biased genes in the latter two species. We highlight the increased sensitivity and improved power of sex-biased gene detection methods when using our testis/ovary data versus male and female whole body transcriptome data. We thus provide a resource specifically designed to accurately identify and characterize sex-biased genes across Drosophila. This dataset is available through NCBI GEO accession GSE52058. Ivyspring International Publisher 2014-03-10 /pmc/articles/PMC4091448/ /pubmed/25031657 http://dx.doi.org/10.7150/jgen.7955 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Short Research Communication
VanKuren, Nicholas W.
Vibranovski, Maria D.
A Novel Dataset for Identifying Sex-Biased Genes in Drosophila
title A Novel Dataset for Identifying Sex-Biased Genes in Drosophila
title_full A Novel Dataset for Identifying Sex-Biased Genes in Drosophila
title_fullStr A Novel Dataset for Identifying Sex-Biased Genes in Drosophila
title_full_unstemmed A Novel Dataset for Identifying Sex-Biased Genes in Drosophila
title_short A Novel Dataset for Identifying Sex-Biased Genes in Drosophila
title_sort novel dataset for identifying sex-biased genes in drosophila
topic Short Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091448/
https://www.ncbi.nlm.nih.gov/pubmed/25031657
http://dx.doi.org/10.7150/jgen.7955
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