Functional comparison of single-chain and two-chain anti-CD3-based bispecific antibodies in gene immunotherapy applications

Gene therapy to achieve in vivo secretion of recombinant anti-CD3 x anti-tumor bispecific antibodies in cancer patients is being explored as a strategy to counterbalance rapid renal elimination, thereby sustaining levels of bispecific antibodies in the therapeutic range. Here, we performed a compara...

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Detalles Bibliográficos
Autores principales: Compte, Marta, Álvarez-Cienfuegos, Ana, Nuñez-Prado, Natalia, Sainz-Pastor, Noelia, Blanco-Toribio, Ana, Pescador, Nuria, Sanz, Laura, Álvarez-Vallina, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091452/
https://www.ncbi.nlm.nih.gov/pubmed/25057445
http://dx.doi.org/10.4161/onci.28810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091452/
https://www.ncbi.nlm.nih.gov/pubmed/25057445
http://dx.doi.org/10.4161/onci.28810

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