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Inflammation, ectopic fat and lipid metabolism: view from the chair
How meals containing large amounts of lipids induce insulin resistance in the short and long term remains a topic of intense research. Speakers of the afternoon session showed recent findings on the modulation of mitochondria-induced oxidative stress by energy substrates, both in chronic and acute (...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091457/ https://www.ncbi.nlm.nih.gov/pubmed/25018873 http://dx.doi.org/10.1038/ijosup.2012.19 |
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author | Picard, F Deshaies, Y |
author_facet | Picard, F Deshaies, Y |
author_sort | Picard, F |
collection | PubMed |
description | How meals containing large amounts of lipids induce insulin resistance in the short and long term remains a topic of intense research. Speakers of the afternoon session showed recent findings on the modulation of mitochondria-induced oxidative stress by energy substrates, both in chronic and acute (single high-fat intake) contexts, which have enabled a better understanding of insulin action at the molecular and cellular levels. These advances are highly amenable to being combined with innovative, elegant imaging techniques to look at the fate of these energy substrates at the in vivo level within optimally defined experimental protocols, both in human and nonhuman models. |
format | Online Article Text |
id | pubmed-4091457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-40914572014-07-11 Inflammation, ectopic fat and lipid metabolism: view from the chair Picard, F Deshaies, Y Int J Obes Suppl Overview How meals containing large amounts of lipids induce insulin resistance in the short and long term remains a topic of intense research. Speakers of the afternoon session showed recent findings on the modulation of mitochondria-induced oxidative stress by energy substrates, both in chronic and acute (single high-fat intake) contexts, which have enabled a better understanding of insulin action at the molecular and cellular levels. These advances are highly amenable to being combined with innovative, elegant imaging techniques to look at the fate of these energy substrates at the in vivo level within optimally defined experimental protocols, both in human and nonhuman models. Nature Publishing Group 2012-12 2012-12-11 /pmc/articles/PMC4091457/ /pubmed/25018873 http://dx.doi.org/10.1038/ijosup.2012.19 Text en Copyright © 2012 Macmillan Publishers Limited |
spellingShingle | Overview Picard, F Deshaies, Y Inflammation, ectopic fat and lipid metabolism: view from the chair |
title | Inflammation, ectopic fat and lipid metabolism: view from the chair |
title_full | Inflammation, ectopic fat and lipid metabolism: view from the chair |
title_fullStr | Inflammation, ectopic fat and lipid metabolism: view from the chair |
title_full_unstemmed | Inflammation, ectopic fat and lipid metabolism: view from the chair |
title_short | Inflammation, ectopic fat and lipid metabolism: view from the chair |
title_sort | inflammation, ectopic fat and lipid metabolism: view from the chair |
topic | Overview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091457/ https://www.ncbi.nlm.nih.gov/pubmed/25018873 http://dx.doi.org/10.1038/ijosup.2012.19 |
work_keys_str_mv | AT picardf inflammationectopicfatandlipidmetabolismviewfromthechair AT deshaiesy inflammationectopicfatandlipidmetabolismviewfromthechair |