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Inflammation, ectopic fat and lipid metabolism: view from the chair

How meals containing large amounts of lipids induce insulin resistance in the short and long term remains a topic of intense research. Speakers of the afternoon session showed recent findings on the modulation of mitochondria-induced oxidative stress by energy substrates, both in chronic and acute (...

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Detalles Bibliográficos
Autores principales: Picard, F, Deshaies, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091457/
https://www.ncbi.nlm.nih.gov/pubmed/25018873
http://dx.doi.org/10.1038/ijosup.2012.19
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author Picard, F
Deshaies, Y
author_facet Picard, F
Deshaies, Y
author_sort Picard, F
collection PubMed
description How meals containing large amounts of lipids induce insulin resistance in the short and long term remains a topic of intense research. Speakers of the afternoon session showed recent findings on the modulation of mitochondria-induced oxidative stress by energy substrates, both in chronic and acute (single high-fat intake) contexts, which have enabled a better understanding of insulin action at the molecular and cellular levels. These advances are highly amenable to being combined with innovative, elegant imaging techniques to look at the fate of these energy substrates at the in vivo level within optimally defined experimental protocols, both in human and nonhuman models.
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spelling pubmed-40914572014-07-11 Inflammation, ectopic fat and lipid metabolism: view from the chair Picard, F Deshaies, Y Int J Obes Suppl Overview How meals containing large amounts of lipids induce insulin resistance in the short and long term remains a topic of intense research. Speakers of the afternoon session showed recent findings on the modulation of mitochondria-induced oxidative stress by energy substrates, both in chronic and acute (single high-fat intake) contexts, which have enabled a better understanding of insulin action at the molecular and cellular levels. These advances are highly amenable to being combined with innovative, elegant imaging techniques to look at the fate of these energy substrates at the in vivo level within optimally defined experimental protocols, both in human and nonhuman models. Nature Publishing Group 2012-12 2012-12-11 /pmc/articles/PMC4091457/ /pubmed/25018873 http://dx.doi.org/10.1038/ijosup.2012.19 Text en Copyright © 2012 Macmillan Publishers Limited
spellingShingle Overview
Picard, F
Deshaies, Y
Inflammation, ectopic fat and lipid metabolism: view from the chair
title Inflammation, ectopic fat and lipid metabolism: view from the chair
title_full Inflammation, ectopic fat and lipid metabolism: view from the chair
title_fullStr Inflammation, ectopic fat and lipid metabolism: view from the chair
title_full_unstemmed Inflammation, ectopic fat and lipid metabolism: view from the chair
title_short Inflammation, ectopic fat and lipid metabolism: view from the chair
title_sort inflammation, ectopic fat and lipid metabolism: view from the chair
topic Overview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091457/
https://www.ncbi.nlm.nih.gov/pubmed/25018873
http://dx.doi.org/10.1038/ijosup.2012.19
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