Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells

Hexokinase II (HKII), a key enzyme of glycolysis, is widely over-expressed in cancer cells. 3-bromopyruvate (3-BrPA), an inhibitor of HK II, has been proposed as a specific antitumor agent. Autophagy is a process that regulates the balance between protein synthesis and protein degradation. Autophagy...

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Detalles Bibliográficos
Autores principales: Zhang, Qianwen, Zhang, Yuanyuan, Zhang, Pei, Chao, Zhenhua, Xia, Fei, Jiang, Chenchen, Zhang, Xudong, Jiang, Zhiwen, Liu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091531/
https://www.ncbi.nlm.nih.gov/pubmed/25053988

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