Epigenetic remodeling combined with photodynamic therapy elicits anticancer immune responses

Photodynamic therapy has been shown to induce strong immunity against tumor cells expressing exogenous tumor-associated antigens (TAAs), including P1A antigen. Cancer cells can evade the immune system by epigenetic silencing of TAAs, while DNA methyltransferase inhibitors, such as 5-aza-2’-deoxycyti...

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Autores principales: Wachowska, Malgorzata, Gabrysiak, Magdalena, Golab, Jakub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091536/
https://www.ncbi.nlm.nih.gov/pubmed/25057447
http://dx.doi.org/10.4161/onci.28837
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author Wachowska, Malgorzata
Gabrysiak, Magdalena
Golab, Jakub
author_facet Wachowska, Malgorzata
Gabrysiak, Magdalena
Golab, Jakub
author_sort Wachowska, Malgorzata
collection PubMed
description Photodynamic therapy has been shown to induce strong immunity against tumor cells expressing exogenous tumor-associated antigens (TAAs), including P1A antigen. Cancer cells can evade the immune system by epigenetic silencing of TAAs, while DNA methyltransferase inhibitors, such as 5-aza-2’-deoxycytidine (5-aza-dC) can restore the expression of silenced or downregulated TAA. Thus, epigenetic remodeling with 5-aza-dC combined with PDT can elicit robust and durable antitumor immunity.
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spelling pubmed-40915362014-07-23 Epigenetic remodeling combined with photodynamic therapy elicits anticancer immune responses Wachowska, Malgorzata Gabrysiak, Magdalena Golab, Jakub Oncoimmunology Author's View Photodynamic therapy has been shown to induce strong immunity against tumor cells expressing exogenous tumor-associated antigens (TAAs), including P1A antigen. Cancer cells can evade the immune system by epigenetic silencing of TAAs, while DNA methyltransferase inhibitors, such as 5-aza-2’-deoxycytidine (5-aza-dC) can restore the expression of silenced or downregulated TAA. Thus, epigenetic remodeling with 5-aza-dC combined with PDT can elicit robust and durable antitumor immunity. Landes Bioscience 2014-05-15 /pmc/articles/PMC4091536/ /pubmed/25057447 http://dx.doi.org/10.4161/onci.28837 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Wachowska, Malgorzata
Gabrysiak, Magdalena
Golab, Jakub
Epigenetic remodeling combined with photodynamic therapy elicits anticancer immune responses
title Epigenetic remodeling combined with photodynamic therapy elicits anticancer immune responses
title_full Epigenetic remodeling combined with photodynamic therapy elicits anticancer immune responses
title_fullStr Epigenetic remodeling combined with photodynamic therapy elicits anticancer immune responses
title_full_unstemmed Epigenetic remodeling combined with photodynamic therapy elicits anticancer immune responses
title_short Epigenetic remodeling combined with photodynamic therapy elicits anticancer immune responses
title_sort epigenetic remodeling combined with photodynamic therapy elicits anticancer immune responses
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091536/
https://www.ncbi.nlm.nih.gov/pubmed/25057447
http://dx.doi.org/10.4161/onci.28837
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