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Location, location, location: The relationship of anatomic site, antigen expression, and T-cell infiltration in human melanoma metastases
Metastatic cell heterogeneity presents a significant obstacle to the development of targeted molecular and immunotherapeutics. Profiling of melanocyte differentiation antigens has revealed a nonstochastic, site-specific pattern of expression in metastases that was highest in brain, intermediate in s...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091537/ https://www.ncbi.nlm.nih.gov/pubmed/25057451 http://dx.doi.org/10.4161/onci.28963 |
| _version_ | 1782480779783176192 |
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| author | Bartlett, Edmund K Kammula, Udai S |
| author_facet | Bartlett, Edmund K Kammula, Udai S |
| author_sort | Bartlett, Edmund K |
| collection | PubMed |
| description | Metastatic cell heterogeneity presents a significant obstacle to the development of targeted molecular and immunotherapeutics. Profiling of melanocyte differentiation antigens has revealed a nonstochastic, site-specific pattern of expression in metastases that was highest in brain, intermediate in soft tissues/lymph nodes, and lowest in visceral sites. Site-specific antigen heterogeneity, thus, is an important confounding factor to consider when assessing the potential efficacy of antigen-specific therapies. |
| format | Online Article Text |
| id | pubmed-4091537 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-40915372014-07-23 Location, location, location: The relationship of anatomic site, antigen expression, and T-cell infiltration in human melanoma metastases Bartlett, Edmund K Kammula, Udai S Oncoimmunology Author's View Metastatic cell heterogeneity presents a significant obstacle to the development of targeted molecular and immunotherapeutics. Profiling of melanocyte differentiation antigens has revealed a nonstochastic, site-specific pattern of expression in metastases that was highest in brain, intermediate in soft tissues/lymph nodes, and lowest in visceral sites. Site-specific antigen heterogeneity, thus, is an important confounding factor to consider when assessing the potential efficacy of antigen-specific therapies. Landes Bioscience 2014-05-23 /pmc/articles/PMC4091537/ /pubmed/25057451 http://dx.doi.org/10.4161/onci.28963 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Author's View Bartlett, Edmund K Kammula, Udai S Location, location, location: The relationship of anatomic site, antigen expression, and T-cell infiltration in human melanoma metastases |
| title | Location, location, location: The relationship of anatomic site, antigen expression, and T-cell infiltration in human melanoma metastases |
| title_full | Location, location, location: The relationship of anatomic site, antigen expression, and T-cell infiltration in human melanoma metastases |
| title_fullStr | Location, location, location: The relationship of anatomic site, antigen expression, and T-cell infiltration in human melanoma metastases |
| title_full_unstemmed | Location, location, location: The relationship of anatomic site, antigen expression, and T-cell infiltration in human melanoma metastases |
| title_short | Location, location, location: The relationship of anatomic site, antigen expression, and T-cell infiltration in human melanoma metastases |
| title_sort | location, location, location: the relationship of anatomic site, antigen expression, and t-cell infiltration in human melanoma metastases |
| topic | Author's View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091537/ https://www.ncbi.nlm.nih.gov/pubmed/25057451 http://dx.doi.org/10.4161/onci.28963 |
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