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Oral drug treatments in patients with erectile dysfunction and multiple comorbidities: a retrospective observational study

OBJECTIVE: To investigate factors associated with demographic/clinical characteristics and drug selection in patients with erectile dysfunction (ED). The prevalence of ED is increasing worldwide. Studies have shown that ED is associated with age, lifestyle and comorbidities. However, the factors ass...

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Autores principales: Zaman Huri, Hasniza, Lian Choo, Tee, Sulaiman, Che Zuraini, Mark, Raymond, Abdul Razack, Azad Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091539/
https://www.ncbi.nlm.nih.gov/pubmed/25001396
http://dx.doi.org/10.1136/bmjopen-2014-005381
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author Zaman Huri, Hasniza
Lian Choo, Tee
Sulaiman, Che Zuraini
Mark, Raymond
Abdul Razack, Azad Hassan
author_facet Zaman Huri, Hasniza
Lian Choo, Tee
Sulaiman, Che Zuraini
Mark, Raymond
Abdul Razack, Azad Hassan
author_sort Zaman Huri, Hasniza
collection PubMed
description OBJECTIVE: To investigate factors associated with demographic/clinical characteristics and drug selection in patients with erectile dysfunction (ED). The prevalence of ED is increasing worldwide. Studies have shown that ED is associated with age, lifestyle and comorbidities. However, the factors associated with patient characteristics as well as drug selection are incompletely understood. SETTING: A tertiary medical centre in Kuala Lumpur, Malaysia. PARTICIPANTS: A total of 219 patients (range 23–80 years) who had received phosphodiesterase type-5 (PDE-5) inhibitors as ED treatment were evaluated. INCLUSION CRITERIA: Adult patients aged ≥18 years, diagnosed with ED, and prescribed with sildenafil, tadalafil or vardenafil. EXCLUSION CRITERIA: Patients diagnosed with ED but who did not receive any PDE-5 inhibitor, or those with missing data. PRIMARY AND SECONDARY OUTCOME MEASURES: Factors associated with demographic and clinical characteristics as well as drug selection were assessed. RESULTS: Ischaemic heart disease (p=0.025), benign prostatic hyperplasia (p<0.001), obesity (p=0.005), lower urinary tract symptoms (LUTS) (p=0.006) and α-blockers (p<0.001) were significantly associated with elderly patients with ED. Additionally, LUTS (p=0.038) and α-blockers (p=0.008) were significantly associated with the selection of PDE-5 inhibitor. CONCLUSIONS: These data showed that elderly patients with ED were significantly associated with comorbidities and α-blockers, whereas LUTS and α blockers were associated with drug selection.
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spelling pubmed-40915392014-07-11 Oral drug treatments in patients with erectile dysfunction and multiple comorbidities: a retrospective observational study Zaman Huri, Hasniza Lian Choo, Tee Sulaiman, Che Zuraini Mark, Raymond Abdul Razack, Azad Hassan BMJ Open Urology OBJECTIVE: To investigate factors associated with demographic/clinical characteristics and drug selection in patients with erectile dysfunction (ED). The prevalence of ED is increasing worldwide. Studies have shown that ED is associated with age, lifestyle and comorbidities. However, the factors associated with patient characteristics as well as drug selection are incompletely understood. SETTING: A tertiary medical centre in Kuala Lumpur, Malaysia. PARTICIPANTS: A total of 219 patients (range 23–80 years) who had received phosphodiesterase type-5 (PDE-5) inhibitors as ED treatment were evaluated. INCLUSION CRITERIA: Adult patients aged ≥18 years, diagnosed with ED, and prescribed with sildenafil, tadalafil or vardenafil. EXCLUSION CRITERIA: Patients diagnosed with ED but who did not receive any PDE-5 inhibitor, or those with missing data. PRIMARY AND SECONDARY OUTCOME MEASURES: Factors associated with demographic and clinical characteristics as well as drug selection were assessed. RESULTS: Ischaemic heart disease (p=0.025), benign prostatic hyperplasia (p<0.001), obesity (p=0.005), lower urinary tract symptoms (LUTS) (p=0.006) and α-blockers (p<0.001) were significantly associated with elderly patients with ED. Additionally, LUTS (p=0.038) and α-blockers (p=0.008) were significantly associated with the selection of PDE-5 inhibitor. CONCLUSIONS: These data showed that elderly patients with ED were significantly associated with comorbidities and α-blockers, whereas LUTS and α blockers were associated with drug selection. BMJ Publishing Group 2014-07-07 /pmc/articles/PMC4091539/ /pubmed/25001396 http://dx.doi.org/10.1136/bmjopen-2014-005381 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Urology
Zaman Huri, Hasniza
Lian Choo, Tee
Sulaiman, Che Zuraini
Mark, Raymond
Abdul Razack, Azad Hassan
Oral drug treatments in patients with erectile dysfunction and multiple comorbidities: a retrospective observational study
title Oral drug treatments in patients with erectile dysfunction and multiple comorbidities: a retrospective observational study
title_full Oral drug treatments in patients with erectile dysfunction and multiple comorbidities: a retrospective observational study
title_fullStr Oral drug treatments in patients with erectile dysfunction and multiple comorbidities: a retrospective observational study
title_full_unstemmed Oral drug treatments in patients with erectile dysfunction and multiple comorbidities: a retrospective observational study
title_short Oral drug treatments in patients with erectile dysfunction and multiple comorbidities: a retrospective observational study
title_sort oral drug treatments in patients with erectile dysfunction and multiple comorbidities: a retrospective observational study
topic Urology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091539/
https://www.ncbi.nlm.nih.gov/pubmed/25001396
http://dx.doi.org/10.1136/bmjopen-2014-005381
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