Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides

Type II natural killer T (NKT) cells in cancer immunity are typically associated with suppression of tumor immunosurveillance through secretion of IL-13. We previously demonstrated that CpG oligonucleotide therapy activated Type II NKT cells to produce T helper type 1 (Th1) rather than T helper type...

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Detalles Bibliográficos
Autores principales: Zhao, Jie, Bagchi, Sreya, Wang, Chyung-Ru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091550/
https://www.ncbi.nlm.nih.gov/pubmed/25057452
http://dx.doi.org/10.4161/onci.28977
Descripción
Sumario:Type II natural killer T (NKT) cells in cancer immunity are typically associated with suppression of tumor immunosurveillance through secretion of IL-13. We previously demonstrated that CpG oligonucleotide therapy activated Type II NKT cells to produce T helper type 1 (Th1) rather than T helper type 2 (Th2) cytokines. This cytokine skewing may manifest in Type II NKT cell antitumor properties in an immunotherapeutic setting.

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