Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides

Type II natural killer T (NKT) cells in cancer immunity are typically associated with suppression of tumor immunosurveillance through secretion of IL-13. We previously demonstrated that CpG oligonucleotide therapy activated Type II NKT cells to produce T helper type 1 (Th1) rather than T helper type...

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Detalles Bibliográficos
Autores principales: Zhao, Jie, Bagchi, Sreya, Wang, Chyung-Ru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091550/
https://www.ncbi.nlm.nih.gov/pubmed/25057452
http://dx.doi.org/10.4161/onci.28977
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author Zhao, Jie
Bagchi, Sreya
Wang, Chyung-Ru
author_facet Zhao, Jie
Bagchi, Sreya
Wang, Chyung-Ru
author_sort Zhao, Jie
collection PubMed
description Type II natural killer T (NKT) cells in cancer immunity are typically associated with suppression of tumor immunosurveillance through secretion of IL-13. We previously demonstrated that CpG oligonucleotide therapy activated Type II NKT cells to produce T helper type 1 (Th1) rather than T helper type 2 (Th2) cytokines. This cytokine skewing may manifest in Type II NKT cell antitumor properties in an immunotherapeutic setting.
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spelling pubmed-40915502014-07-23 Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides Zhao, Jie Bagchi, Sreya Wang, Chyung-Ru Oncoimmunology Author's View Type II natural killer T (NKT) cells in cancer immunity are typically associated with suppression of tumor immunosurveillance through secretion of IL-13. We previously demonstrated that CpG oligonucleotide therapy activated Type II NKT cells to produce T helper type 1 (Th1) rather than T helper type 2 (Th2) cytokines. This cytokine skewing may manifest in Type II NKT cell antitumor properties in an immunotherapeutic setting. Landes Bioscience 2014-05-23 /pmc/articles/PMC4091550/ /pubmed/25057452 http://dx.doi.org/10.4161/onci.28977 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Zhao, Jie
Bagchi, Sreya
Wang, Chyung-Ru
Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides
title Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides
title_full Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides
title_fullStr Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides
title_full_unstemmed Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides
title_short Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides
title_sort type ii natural killer t cells foster the antitumor activity of cpg-oligodeoxynucleotides
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091550/
https://www.ncbi.nlm.nih.gov/pubmed/25057452
http://dx.doi.org/10.4161/onci.28977
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