Changes in the Morphology and Proliferation of Astrocytes Induced by Two Modalities of Chemically Functionalized Single-Walled Carbon Nanotubes are Differentially Mediated by Glial Fibrillary Acidic Protein

[Image: see text] Alterations in glial fibrillary acidic protein (GFAP) levels accompany the changes in the morphology and proliferation of astrocytes induced by colloidal solutes and films of carbon nanotubes (CNTs). To determine if GFAP is required for the effects of CNTs on astrocytes, we used as...

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Autores principales: Gottipati, Manoj K., Bekyarova, Elena, Brenner, Michael, Haddon, Robert C., Parpura, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091642/
https://www.ncbi.nlm.nih.gov/pubmed/24875845
http://dx.doi.org/10.1021/nl4048114
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author Gottipati, Manoj K.
Bekyarova, Elena
Brenner, Michael
Haddon, Robert C.
Parpura, Vladimir
author_facet Gottipati, Manoj K.
Bekyarova, Elena
Brenner, Michael
Haddon, Robert C.
Parpura, Vladimir
author_sort Gottipati, Manoj K.
collection PubMed
description [Image: see text] Alterations in glial fibrillary acidic protein (GFAP) levels accompany the changes in the morphology and proliferation of astrocytes induced by colloidal solutes and films of carbon nanotubes (CNTs). To determine if GFAP is required for the effects of CNTs on astrocytes, we used astrocytes isolated from GFAP null mice. We find that selected astrocytic changes induced by CNTs are mediated by GFAP, i.e., perimeter, shape, and cell death for solutes, and proliferation for films.
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spelling pubmed-40916422015-05-29 Changes in the Morphology and Proliferation of Astrocytes Induced by Two Modalities of Chemically Functionalized Single-Walled Carbon Nanotubes are Differentially Mediated by Glial Fibrillary Acidic Protein Gottipati, Manoj K. Bekyarova, Elena Brenner, Michael Haddon, Robert C. Parpura, Vladimir Nano Lett [Image: see text] Alterations in glial fibrillary acidic protein (GFAP) levels accompany the changes in the morphology and proliferation of astrocytes induced by colloidal solutes and films of carbon nanotubes (CNTs). To determine if GFAP is required for the effects of CNTs on astrocytes, we used astrocytes isolated from GFAP null mice. We find that selected astrocytic changes induced by CNTs are mediated by GFAP, i.e., perimeter, shape, and cell death for solutes, and proliferation for films. American Chemical Society 2014-05-29 2014-07-09 /pmc/articles/PMC4091642/ /pubmed/24875845 http://dx.doi.org/10.1021/nl4048114 Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Gottipati, Manoj K.
Bekyarova, Elena
Brenner, Michael
Haddon, Robert C.
Parpura, Vladimir
Changes in the Morphology and Proliferation of Astrocytes Induced by Two Modalities of Chemically Functionalized Single-Walled Carbon Nanotubes are Differentially Mediated by Glial Fibrillary Acidic Protein
title Changes in the Morphology and Proliferation of Astrocytes Induced by Two Modalities of Chemically Functionalized Single-Walled Carbon Nanotubes are Differentially Mediated by Glial Fibrillary Acidic Protein
title_full Changes in the Morphology and Proliferation of Astrocytes Induced by Two Modalities of Chemically Functionalized Single-Walled Carbon Nanotubes are Differentially Mediated by Glial Fibrillary Acidic Protein
title_fullStr Changes in the Morphology and Proliferation of Astrocytes Induced by Two Modalities of Chemically Functionalized Single-Walled Carbon Nanotubes are Differentially Mediated by Glial Fibrillary Acidic Protein
title_full_unstemmed Changes in the Morphology and Proliferation of Astrocytes Induced by Two Modalities of Chemically Functionalized Single-Walled Carbon Nanotubes are Differentially Mediated by Glial Fibrillary Acidic Protein
title_short Changes in the Morphology and Proliferation of Astrocytes Induced by Two Modalities of Chemically Functionalized Single-Walled Carbon Nanotubes are Differentially Mediated by Glial Fibrillary Acidic Protein
title_sort changes in the morphology and proliferation of astrocytes induced by two modalities of chemically functionalized single-walled carbon nanotubes are differentially mediated by glial fibrillary acidic protein
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091642/
https://www.ncbi.nlm.nih.gov/pubmed/24875845
http://dx.doi.org/10.1021/nl4048114
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