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A Broadly Conserved G-Protein-Coupled Receptor Kinase Phosphorylation Mechanism Controls Drosophila Smoothened Activity

Hedgehog (Hh) signaling is essential for normal growth, patterning, and homeostasis of many tissues in diverse organisms, and is misregulated in a variety of diseases including cancer. Cytoplasmic Hedgehog signaling is activated by multisite phosphorylation of the seven-pass transmembrane protein Sm...

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Detalles Bibliográficos
Autores principales:	Maier, Dominic, Cheng, Shuofei, Faubert, Denis, Hipfner, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091690/ https://www.ncbi.nlm.nih.gov/pubmed/25009998 http://dx.doi.org/10.1371/journal.pgen.1004399

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