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Biophysical Fitness Landscapes for Transcription Factor Binding Sites

Phenotypic states and evolutionary trajectories available to cell populations are ultimately dictated by complex interactions among DNA, RNA, proteins, and other molecular species. Here we study how evolution of gene regulation in a single-cell eukaryote S. cerevisiae is affected by interactions bet...

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Detalles Bibliográficos
Autores principales: Haldane, Allan, Manhart, Michael, Morozov, Alexandre V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091707/
https://www.ncbi.nlm.nih.gov/pubmed/25010228
http://dx.doi.org/10.1371/journal.pcbi.1003683