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Age-Associated Sperm DNA Methylation Alterations: Possible Implications in Offspring Disease Susceptibility

Recent evidence demonstrates a role for paternal aging on offspring disease susceptibility. It is well established that various neuropsychiatric disorders (schizophrenia, autism, etc.), trinucleotide expansion associated diseases (myotonic dystrophy, Huntington's, etc.) and even some forms of c...

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Detalles Bibliográficos
Autores principales: Jenkins, Timothy G., Aston, Kenneth I., Pflueger, Christian, Cairns, Bradley R., Carrell, Douglas T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091790/
https://www.ncbi.nlm.nih.gov/pubmed/25010591
http://dx.doi.org/10.1371/journal.pgen.1004458