Cargando…
Involvement of macrophage migration inhibitory factor and its receptor (CD74) in human breast cancer
Macrophage migration inhibitory factor (MIF) and its receptor CD74 appear to be involved in tumorigenesis. We evaluated, by immunohistochemical staining, the tissue expression and distribution of MIF and CD74 in serial sections of human invasive breast cancer tumor specimens. The serum MIF level was...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091881/ https://www.ncbi.nlm.nih.gov/pubmed/24939415 http://dx.doi.org/10.3892/or.2014.3272 |
_version_ | 1782480811959779328 |
---|---|
author | RICHARD, VINCENT KINDT, NADÈGE DECAESTECKER, CHRISTINE GABIUS, HANS-JOACHIM LAURENT, GUY NOËL, JEAN-CHRISTOPHE SAUSSEZ, SVEN |
author_facet | RICHARD, VINCENT KINDT, NADÈGE DECAESTECKER, CHRISTINE GABIUS, HANS-JOACHIM LAURENT, GUY NOËL, JEAN-CHRISTOPHE SAUSSEZ, SVEN |
author_sort | RICHARD, VINCENT |
collection | PubMed |
description | Macrophage migration inhibitory factor (MIF) and its receptor CD74 appear to be involved in tumorigenesis. We evaluated, by immunohistochemical staining, the tissue expression and distribution of MIF and CD74 in serial sections of human invasive breast cancer tumor specimens. The serum MIF level was also determined in breast cancer patients. We showed a significant increase in serum MIF average levels in breast cancer patients compared to healthy individuals. MIF tissue expression, quantified by a modified Allred score, was strongly increased in carcinoma compared to tumor-free specimens, in the cancer cells and in the peritumoral stroma, with fibroblasts the most intensely stained. We did not find any significant correlation with histoprognostic factors, except for a significant inverse correlation between tumor size and MIF stromal positivity. CD74 staining was heterogeneous and significantly decreased in cancer cells but increased in the surrounding stroma, namely in lymphocytes, macrophages and vessel endothelium. There was no significant variation according to classical histoprognostic factors, except that CD74 stromal expression was significantly correlated with triple-negative receptor (TRN) status and the absence of estrogen receptors. In conclusion, our data support the concept of a functional role of MIF in human breast cancer. In addition to auto- and paracrine effects on cancer cells, MIF could contribute to shape the tumor microenvironment leading to immunomodulation and angiogenesis. Interfering with MIF effects in breast tumors in a therapeutic perspective remains an attractive but complex challenge. Level of co-expression of MIF and CD74 could be a surrogate marker for efficacy of anti-angiogenic drugs, particularly in TRN breast cancer tumor. |
format | Online Article Text |
id | pubmed-4091881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-40918812014-07-11 Involvement of macrophage migration inhibitory factor and its receptor (CD74) in human breast cancer RICHARD, VINCENT KINDT, NADÈGE DECAESTECKER, CHRISTINE GABIUS, HANS-JOACHIM LAURENT, GUY NOËL, JEAN-CHRISTOPHE SAUSSEZ, SVEN Oncol Rep Articles Macrophage migration inhibitory factor (MIF) and its receptor CD74 appear to be involved in tumorigenesis. We evaluated, by immunohistochemical staining, the tissue expression and distribution of MIF and CD74 in serial sections of human invasive breast cancer tumor specimens. The serum MIF level was also determined in breast cancer patients. We showed a significant increase in serum MIF average levels in breast cancer patients compared to healthy individuals. MIF tissue expression, quantified by a modified Allred score, was strongly increased in carcinoma compared to tumor-free specimens, in the cancer cells and in the peritumoral stroma, with fibroblasts the most intensely stained. We did not find any significant correlation with histoprognostic factors, except for a significant inverse correlation between tumor size and MIF stromal positivity. CD74 staining was heterogeneous and significantly decreased in cancer cells but increased in the surrounding stroma, namely in lymphocytes, macrophages and vessel endothelium. There was no significant variation according to classical histoprognostic factors, except that CD74 stromal expression was significantly correlated with triple-negative receptor (TRN) status and the absence of estrogen receptors. In conclusion, our data support the concept of a functional role of MIF in human breast cancer. In addition to auto- and paracrine effects on cancer cells, MIF could contribute to shape the tumor microenvironment leading to immunomodulation and angiogenesis. Interfering with MIF effects in breast tumors in a therapeutic perspective remains an attractive but complex challenge. Level of co-expression of MIF and CD74 could be a surrogate marker for efficacy of anti-angiogenic drugs, particularly in TRN breast cancer tumor. D.A. Spandidos 2014-08 2014-06-16 /pmc/articles/PMC4091881/ /pubmed/24939415 http://dx.doi.org/10.3892/or.2014.3272 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles RICHARD, VINCENT KINDT, NADÈGE DECAESTECKER, CHRISTINE GABIUS, HANS-JOACHIM LAURENT, GUY NOËL, JEAN-CHRISTOPHE SAUSSEZ, SVEN Involvement of macrophage migration inhibitory factor and its receptor (CD74) in human breast cancer |
title | Involvement of macrophage migration inhibitory factor and its receptor (CD74) in human breast cancer |
title_full | Involvement of macrophage migration inhibitory factor and its receptor (CD74) in human breast cancer |
title_fullStr | Involvement of macrophage migration inhibitory factor and its receptor (CD74) in human breast cancer |
title_full_unstemmed | Involvement of macrophage migration inhibitory factor and its receptor (CD74) in human breast cancer |
title_short | Involvement of macrophage migration inhibitory factor and its receptor (CD74) in human breast cancer |
title_sort | involvement of macrophage migration inhibitory factor and its receptor (cd74) in human breast cancer |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091881/ https://www.ncbi.nlm.nih.gov/pubmed/24939415 http://dx.doi.org/10.3892/or.2014.3272 |
work_keys_str_mv | AT richardvincent involvementofmacrophagemigrationinhibitoryfactoranditsreceptorcd74inhumanbreastcancer AT kindtnadege involvementofmacrophagemigrationinhibitoryfactoranditsreceptorcd74inhumanbreastcancer AT decaesteckerchristine involvementofmacrophagemigrationinhibitoryfactoranditsreceptorcd74inhumanbreastcancer AT gabiushansjoachim involvementofmacrophagemigrationinhibitoryfactoranditsreceptorcd74inhumanbreastcancer AT laurentguy involvementofmacrophagemigrationinhibitoryfactoranditsreceptorcd74inhumanbreastcancer AT noeljeanchristophe involvementofmacrophagemigrationinhibitoryfactoranditsreceptorcd74inhumanbreastcancer AT saussezsven involvementofmacrophagemigrationinhibitoryfactoranditsreceptorcd74inhumanbreastcancer |