The hedgehog’s trick for escaping immunosurveillance: The molecular mechanisms driving myeloid-derived suppressor cell recruitment in hedgehog signaling-dependent tumors

Myeloid-derived suppressor cells (MDSCs) are an important means by which tumor cells evade immunosurveillance. Here, we set out to determine how MDSCs are recruited to tumors in genetically engineered mouse cancer models. Expression of oncogenic and constitutively active SmoM2, a key hedgehog-signal...

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Autor principal: Xie, Jingwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092004/
https://www.ncbi.nlm.nih.gov/pubmed/25054089
http://dx.doi.org/10.4161/onci.29180
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author Xie, Jingwu
author_facet Xie, Jingwu
author_sort Xie, Jingwu
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description Myeloid-derived suppressor cells (MDSCs) are an important means by which tumor cells evade immunosurveillance. Here, we set out to determine how MDSCs are recruited to tumors in genetically engineered mouse cancer models. Expression of oncogenic and constitutively active SmoM2, a key hedgehog-signaling regulatory protein, revealed that MDSC recruitment to the tumor microenvironment is mediated by the CCL2/CCR2 axis in a TGFβ dependent fashion.
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spelling pubmed-40920042014-07-22 The hedgehog’s trick for escaping immunosurveillance: The molecular mechanisms driving myeloid-derived suppressor cell recruitment in hedgehog signaling-dependent tumors Xie, Jingwu Oncoimmunology Author's View Myeloid-derived suppressor cells (MDSCs) are an important means by which tumor cells evade immunosurveillance. Here, we set out to determine how MDSCs are recruited to tumors in genetically engineered mouse cancer models. Expression of oncogenic and constitutively active SmoM2, a key hedgehog-signaling regulatory protein, revealed that MDSC recruitment to the tumor microenvironment is mediated by the CCL2/CCR2 axis in a TGFβ dependent fashion. Landes Bioscience 2014-06-05 /pmc/articles/PMC4092004/ /pubmed/25054089 http://dx.doi.org/10.4161/onci.29180 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Xie, Jingwu
The hedgehog’s trick for escaping immunosurveillance: The molecular mechanisms driving myeloid-derived suppressor cell recruitment in hedgehog signaling-dependent tumors
title The hedgehog’s trick for escaping immunosurveillance: The molecular mechanisms driving myeloid-derived suppressor cell recruitment in hedgehog signaling-dependent tumors
title_full The hedgehog’s trick for escaping immunosurveillance: The molecular mechanisms driving myeloid-derived suppressor cell recruitment in hedgehog signaling-dependent tumors
title_fullStr The hedgehog’s trick for escaping immunosurveillance: The molecular mechanisms driving myeloid-derived suppressor cell recruitment in hedgehog signaling-dependent tumors
title_full_unstemmed The hedgehog’s trick for escaping immunosurveillance: The molecular mechanisms driving myeloid-derived suppressor cell recruitment in hedgehog signaling-dependent tumors
title_short The hedgehog’s trick for escaping immunosurveillance: The molecular mechanisms driving myeloid-derived suppressor cell recruitment in hedgehog signaling-dependent tumors
title_sort hedgehog’s trick for escaping immunosurveillance: the molecular mechanisms driving myeloid-derived suppressor cell recruitment in hedgehog signaling-dependent tumors
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092004/
https://www.ncbi.nlm.nih.gov/pubmed/25054089
http://dx.doi.org/10.4161/onci.29180
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