Anticancer Tc9 cells: Long-lived tumor-killing T cells for adoptive therapy

IL-9-producing cytotoxic T (Tc9) cells represent a unique CD8(+) T-cell subset. These long-lived immune cells possess the capacity to acquire effector function and home to tumor tissues after adoptive transfer. IL-9 is indispensable for Tc9-mediated superior antitumor response. These findings are hi...

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Detalles Bibliográficos
Autores principales: Lu, Yong, Wang, Qiang, Yi, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092006/
https://www.ncbi.nlm.nih.gov/pubmed/25054087
http://dx.doi.org/10.4161/onci.28542
Descripción
Sumario:IL-9-producing cytotoxic T (Tc9) cells represent a unique CD8(+) T-cell subset. These long-lived immune cells possess the capacity to acquire effector function and home to tumor tissues after adoptive transfer. IL-9 is indispensable for Tc9-mediated superior antitumor response. These findings are highly significant and crucial to achieve advances in T cell-based adoptive therapies.

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