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Embryonal rhabdomyosarcoma of the cervix presenting as a cervical polyp in a 16-year-old adolescent: a case report

INTRODUCTION: Embryonal rhabdomyosarcoma of the female genital tract is rare in the cervix. It has been mainly discussed in the context of individual case studies. It tends to occur in children and young women. Treatment ranges from radical surgery to conservative surgery, followed by chemotherapy....

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Autores principales: Jayi, Sofia, Bouguern, Hakima, Fdili, Fatima Zohra, Chaara, Hikmat, Chbani, Leila, Hafidi, Imane, Kamaoui, Imane, Arifi, Samia, Mellas, Naoufal, Bouhafa, Touria, Hassouni, Khalid, Tizniti, Siham, Laamarti, Afaf, Melhouf, My Abdelilah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092352/
https://www.ncbi.nlm.nih.gov/pubmed/24986146
http://dx.doi.org/10.1186/1752-1947-8-241
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author Jayi, Sofia
Bouguern, Hakima
Fdili, Fatima Zohra
Chaara, Hikmat
Chbani, Leila
Hafidi, Imane
Kamaoui, Imane
Arifi, Samia
Mellas, Naoufal
Bouhafa, Touria
Hassouni, Khalid
Tizniti, Siham
Laamarti, Afaf
Melhouf, My Abdelilah
author_facet Jayi, Sofia
Bouguern, Hakima
Fdili, Fatima Zohra
Chaara, Hikmat
Chbani, Leila
Hafidi, Imane
Kamaoui, Imane
Arifi, Samia
Mellas, Naoufal
Bouhafa, Touria
Hassouni, Khalid
Tizniti, Siham
Laamarti, Afaf
Melhouf, My Abdelilah
author_sort Jayi, Sofia
collection PubMed
description INTRODUCTION: Embryonal rhabdomyosarcoma of the female genital tract is rare in the cervix. It has been mainly discussed in the context of individual case studies. It tends to occur in children and young women. Treatment ranges from radical surgery to conservative surgery, followed by chemotherapy. CASE PRESENTATION: A 16-year-old Moroccan adolescent girl presented to our center with a protruding mass from her vaginal introitus, as a polyp of 6cm. An examination revealed a polyp within her vagina, thought to be arising from her cervix and a polypectomy was performed. Microscopic findings are consistent with an embryonal rhabdomyosarcoma (botryoide type). A computed tomography of her thorax, abdomen and pelvis were performed and residual disease was found as a mass located at her cervix, which measured approximately 4.5cm in its widest dimensions, without evidence of metastatic disease. Due to the fact that she is young, after discussions in a multidisciplinary meeting, she was subsequently treated with four cycles of multi-agent chemotherapy. Two cycles of chemotherapy and radiotherapy were administered due to the lack of response, but she presented vaginal bleeding with persistence of the same mass in computed tomography. Hence a total interadnexal hysterectomy was made. A histologic examination found residual embryonal rhabdomyosarcoma (botryoide type) located in all her cervix and she is currently under chemotherapy. CONCLUSIONS: The presence of a cervical polyp in an adolescent is a gynecologic oddity and must necessarily be examined histologically because it might be a rhabdomyosarcoma. This is extremely important because diagnosis at an early stage of the disease is a highly favorable prognostic factor that allows “fertility-sparing surgery” for these young patients.
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spelling pubmed-40923522014-07-12 Embryonal rhabdomyosarcoma of the cervix presenting as a cervical polyp in a 16-year-old adolescent: a case report Jayi, Sofia Bouguern, Hakima Fdili, Fatima Zohra Chaara, Hikmat Chbani, Leila Hafidi, Imane Kamaoui, Imane Arifi, Samia Mellas, Naoufal Bouhafa, Touria Hassouni, Khalid Tizniti, Siham Laamarti, Afaf Melhouf, My Abdelilah J Med Case Rep Case Report INTRODUCTION: Embryonal rhabdomyosarcoma of the female genital tract is rare in the cervix. It has been mainly discussed in the context of individual case studies. It tends to occur in children and young women. Treatment ranges from radical surgery to conservative surgery, followed by chemotherapy. CASE PRESENTATION: A 16-year-old Moroccan adolescent girl presented to our center with a protruding mass from her vaginal introitus, as a polyp of 6cm. An examination revealed a polyp within her vagina, thought to be arising from her cervix and a polypectomy was performed. Microscopic findings are consistent with an embryonal rhabdomyosarcoma (botryoide type). A computed tomography of her thorax, abdomen and pelvis were performed and residual disease was found as a mass located at her cervix, which measured approximately 4.5cm in its widest dimensions, without evidence of metastatic disease. Due to the fact that she is young, after discussions in a multidisciplinary meeting, she was subsequently treated with four cycles of multi-agent chemotherapy. Two cycles of chemotherapy and radiotherapy were administered due to the lack of response, but she presented vaginal bleeding with persistence of the same mass in computed tomography. Hence a total interadnexal hysterectomy was made. A histologic examination found residual embryonal rhabdomyosarcoma (botryoide type) located in all her cervix and she is currently under chemotherapy. CONCLUSIONS: The presence of a cervical polyp in an adolescent is a gynecologic oddity and must necessarily be examined histologically because it might be a rhabdomyosarcoma. This is extremely important because diagnosis at an early stage of the disease is a highly favorable prognostic factor that allows “fertility-sparing surgery” for these young patients. BioMed Central 2014-07-01 /pmc/articles/PMC4092352/ /pubmed/24986146 http://dx.doi.org/10.1186/1752-1947-8-241 Text en Copyright © 2014 Jayi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Jayi, Sofia
Bouguern, Hakima
Fdili, Fatima Zohra
Chaara, Hikmat
Chbani, Leila
Hafidi, Imane
Kamaoui, Imane
Arifi, Samia
Mellas, Naoufal
Bouhafa, Touria
Hassouni, Khalid
Tizniti, Siham
Laamarti, Afaf
Melhouf, My Abdelilah
Embryonal rhabdomyosarcoma of the cervix presenting as a cervical polyp in a 16-year-old adolescent: a case report
title Embryonal rhabdomyosarcoma of the cervix presenting as a cervical polyp in a 16-year-old adolescent: a case report
title_full Embryonal rhabdomyosarcoma of the cervix presenting as a cervical polyp in a 16-year-old adolescent: a case report
title_fullStr Embryonal rhabdomyosarcoma of the cervix presenting as a cervical polyp in a 16-year-old adolescent: a case report
title_full_unstemmed Embryonal rhabdomyosarcoma of the cervix presenting as a cervical polyp in a 16-year-old adolescent: a case report
title_short Embryonal rhabdomyosarcoma of the cervix presenting as a cervical polyp in a 16-year-old adolescent: a case report
title_sort embryonal rhabdomyosarcoma of the cervix presenting as a cervical polyp in a 16-year-old adolescent: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092352/
https://www.ncbi.nlm.nih.gov/pubmed/24986146
http://dx.doi.org/10.1186/1752-1947-8-241
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