The Possibility of TBC1D21 as a Candidate Gene for Teat Numbers in Pigs

Based on a quantitative traits locus (QTL) study using a F(2) intercross between Landrace and Korean native pigs, a significant QTL affecting teat numbers in SSC7 was identified. The strong positional candidate gene, TBC1D21, was selected due to its biological function for epithelial mesenchymal cel...

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Autores principales: Jin, S., Lee, J. B., Kang, K., Yoo, C. K., Kim, B. M., Park, H. B., Lim, H. T., Cho, I. C., Maharani, D., Lee, J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asian-Australasian Association of Animal Production Societies (AAAP) and Korean Society of Animal Science and Technology (KSAST) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093071/
https://www.ncbi.nlm.nih.gov/pubmed/25049720
http://dx.doi.org/10.5713/ajas.2013.13140
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author Jin, S.
Lee, J. B.
Kang, K.
Yoo, C. K.
Kim, B. M.
Park, H. B.
Lim, H. T.
Cho, I. C.
Maharani, D.
Lee, J. H.
author_facet Jin, S.
Lee, J. B.
Kang, K.
Yoo, C. K.
Kim, B. M.
Park, H. B.
Lim, H. T.
Cho, I. C.
Maharani, D.
Lee, J. H.
author_sort Jin, S.
collection PubMed
description Based on a quantitative traits locus (QTL) study using a F(2) intercross between Landrace and Korean native pigs, a significant QTL affecting teat numbers in SSC7 was identified. The strong positional candidate gene, TBC1D21, was selected due to its biological function for epithelial mesenchymal cell development. Sequence analysis revealed six single nucleotide polymorphisms (SNPs) in the TBC1D21 gene. Among these, two SNP markers, one silent mutation (SNP01) for g.13,050A>G and one missense mutation (SNP04) for c.829A>T (S277C), were genotyped and they showed significant associations with teat number traits (p value = 6.38E-05 for SNP01 and p value = 1.06E-07 for SNP04 with total teat numbers). Further functional validation of these SNPs could give valuable information for understanding the teat number variation in pigs.
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spelling pubmed-40930712014-07-21 The Possibility of TBC1D21 as a Candidate Gene for Teat Numbers in Pigs Jin, S. Lee, J. B. Kang, K. Yoo, C. K. Kim, B. M. Park, H. B. Lim, H. T. Cho, I. C. Maharani, D. Lee, J. H. Asian-Australas J Anim Sci Article Based on a quantitative traits locus (QTL) study using a F(2) intercross between Landrace and Korean native pigs, a significant QTL affecting teat numbers in SSC7 was identified. The strong positional candidate gene, TBC1D21, was selected due to its biological function for epithelial mesenchymal cell development. Sequence analysis revealed six single nucleotide polymorphisms (SNPs) in the TBC1D21 gene. Among these, two SNP markers, one silent mutation (SNP01) for g.13,050A>G and one missense mutation (SNP04) for c.829A>T (S277C), were genotyped and they showed significant associations with teat number traits (p value = 6.38E-05 for SNP01 and p value = 1.06E-07 for SNP04 with total teat numbers). Further functional validation of these SNPs could give valuable information for understanding the teat number variation in pigs. Asian-Australasian Association of Animal Production Societies (AAAP) and Korean Society of Animal Science and Technology (KSAST) 2013-10 /pmc/articles/PMC4093071/ /pubmed/25049720 http://dx.doi.org/10.5713/ajas.2013.13140 Text en Copyright © 2013 by Asian-Australasian Journal of Animal Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/ which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Jin, S.
Lee, J. B.
Kang, K.
Yoo, C. K.
Kim, B. M.
Park, H. B.
Lim, H. T.
Cho, I. C.
Maharani, D.
Lee, J. H.
The Possibility of TBC1D21 as a Candidate Gene for Teat Numbers in Pigs
title The Possibility of TBC1D21 as a Candidate Gene for Teat Numbers in Pigs
title_full The Possibility of TBC1D21 as a Candidate Gene for Teat Numbers in Pigs
title_fullStr The Possibility of TBC1D21 as a Candidate Gene for Teat Numbers in Pigs
title_full_unstemmed The Possibility of TBC1D21 as a Candidate Gene for Teat Numbers in Pigs
title_short The Possibility of TBC1D21 as a Candidate Gene for Teat Numbers in Pigs
title_sort possibility of tbc1d21 as a candidate gene for teat numbers in pigs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093071/
https://www.ncbi.nlm.nih.gov/pubmed/25049720
http://dx.doi.org/10.5713/ajas.2013.13140
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