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Genetic Polymorphisms of the Bovine NOV Gene Are Significantly Associated with Carcass Traits in Korean Cattle
The objective of this study was to investigate single nucleotide polymorphisms (SNPs) in the bovine nephroblastoma overexpressed (NOV) gene and to evaluate whether these polymorphisms affect carcass traits in the Korean cattle population. We resequenced to detect SNPs from 24 unrelated individuals a...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asian-Australasian Association of Animal Production Societies (AAAP) and Korean Society of Animal Science and Technology (KSAST)
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093253/ https://www.ncbi.nlm.nih.gov/pubmed/25049850 http://dx.doi.org/10.5713/ajas.2012.12514 |
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author | Kim, B. S. Kim, S. C. Park, C. M. Lee, S. H. Cho, S. H. Kim, N. K. Jang, G. W. Yoon, D. H. Yang, B. S. Hong, S. K. Seong, H. H. Choi, B. H. |
author_facet | Kim, B. S. Kim, S. C. Park, C. M. Lee, S. H. Cho, S. H. Kim, N. K. Jang, G. W. Yoon, D. H. Yang, B. S. Hong, S. K. Seong, H. H. Choi, B. H. |
author_sort | Kim, B. S. |
collection | PubMed |
description | The objective of this study was to investigate single nucleotide polymorphisms (SNPs) in the bovine nephroblastoma overexpressed (NOV) gene and to evaluate whether these polymorphisms affect carcass traits in the Korean cattle population. We resequenced to detect SNPs from 24 unrelated individuals and identified 19 SNPs within the full 8.4-kb gene, including the 1.5-kb promoter region. Of these 19 SNPs, four were selected for genotyping based on linkage disequilibrium (LD). We genotyped 429 steers to assess the associations of these four SNPs with carcass traits. Statistical analysis revealed that g.7801T>C and g.8379A>C polymorphisms in the NOV gene were associated with carcass weight (p = 0.012 and 0.008, respectively), and the g.2005A>G polymorphism was associated with the back fat thickness (BF) trait (p = 0.0001). One haplotype of the four SNPs (GGTA) was significantly associated with BF (p = 0.0005). Our findings suggest that polymorphisms in the NOV gene may be among the important genetic factors affecting carcass yield in beef cattle. |
format | Online Article Text |
id | pubmed-4093253 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Asian-Australasian Association of Animal Production Societies (AAAP) and Korean Society of Animal Science and Technology (KSAST) |
record_format | MEDLINE/PubMed |
spelling | pubmed-40932532014-07-21 Genetic Polymorphisms of the Bovine NOV Gene Are Significantly Associated with Carcass Traits in Korean Cattle Kim, B. S. Kim, S. C. Park, C. M. Lee, S. H. Cho, S. H. Kim, N. K. Jang, G. W. Yoon, D. H. Yang, B. S. Hong, S. K. Seong, H. H. Choi, B. H. Asian-Australas J Anim Sci Article The objective of this study was to investigate single nucleotide polymorphisms (SNPs) in the bovine nephroblastoma overexpressed (NOV) gene and to evaluate whether these polymorphisms affect carcass traits in the Korean cattle population. We resequenced to detect SNPs from 24 unrelated individuals and identified 19 SNPs within the full 8.4-kb gene, including the 1.5-kb promoter region. Of these 19 SNPs, four were selected for genotyping based on linkage disequilibrium (LD). We genotyped 429 steers to assess the associations of these four SNPs with carcass traits. Statistical analysis revealed that g.7801T>C and g.8379A>C polymorphisms in the NOV gene were associated with carcass weight (p = 0.012 and 0.008, respectively), and the g.2005A>G polymorphism was associated with the back fat thickness (BF) trait (p = 0.0001). One haplotype of the four SNPs (GGTA) was significantly associated with BF (p = 0.0005). Our findings suggest that polymorphisms in the NOV gene may be among the important genetic factors affecting carcass yield in beef cattle. Asian-Australasian Association of Animal Production Societies (AAAP) and Korean Society of Animal Science and Technology (KSAST) 2013-06 /pmc/articles/PMC4093253/ /pubmed/25049850 http://dx.doi.org/10.5713/ajas.2012.12514 Text en Copyright © 2013 by Asian-Australasian Journal of Animal Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/ which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Kim, B. S. Kim, S. C. Park, C. M. Lee, S. H. Cho, S. H. Kim, N. K. Jang, G. W. Yoon, D. H. Yang, B. S. Hong, S. K. Seong, H. H. Choi, B. H. Genetic Polymorphisms of the Bovine NOV Gene Are Significantly Associated with Carcass Traits in Korean Cattle |
title | Genetic Polymorphisms of the Bovine NOV Gene Are Significantly Associated with Carcass Traits in Korean Cattle |
title_full | Genetic Polymorphisms of the Bovine NOV Gene Are Significantly Associated with Carcass Traits in Korean Cattle |
title_fullStr | Genetic Polymorphisms of the Bovine NOV Gene Are Significantly Associated with Carcass Traits in Korean Cattle |
title_full_unstemmed | Genetic Polymorphisms of the Bovine NOV Gene Are Significantly Associated with Carcass Traits in Korean Cattle |
title_short | Genetic Polymorphisms of the Bovine NOV Gene Are Significantly Associated with Carcass Traits in Korean Cattle |
title_sort | genetic polymorphisms of the bovine nov gene are significantly associated with carcass traits in korean cattle |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093253/ https://www.ncbi.nlm.nih.gov/pubmed/25049850 http://dx.doi.org/10.5713/ajas.2012.12514 |
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