Polymorphisms in the Promoter Region of the Chinese Bovine PPARGC1A Gene

The peroxisome proliferator-activated receptor gamma coactivator-1 alpha protein, encoded by the PPARGC1A gene, plays an important role in energy homeostasis. The genetic variations within the PPARGC1A gene promoter region were scanned in 808 Chinese native bovines belonging to three cattle breeds a...

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Autores principales: Li, M. J., Liu, M., Liu, D., Lan, X. Y., Lei, C. Z., Yang, D. Y., Chen, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asian-Australasian Association of Animal Production Societies (AAAP) and Korean Society of Animal Science and Technology (KSAST) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093395/
https://www.ncbi.nlm.nih.gov/pubmed/25049813
http://dx.doi.org/10.5713/ajas.2012.12554
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author Li, M. J.
Liu, M.
Liu, D.
Lan, X. Y.
Lei, C. Z.
Yang, D. Y.
Chen, H.
author_facet Li, M. J.
Liu, M.
Liu, D.
Lan, X. Y.
Lei, C. Z.
Yang, D. Y.
Chen, H.
author_sort Li, M. J.
collection PubMed
description The peroxisome proliferator-activated receptor gamma coactivator-1 alpha protein, encoded by the PPARGC1A gene, plays an important role in energy homeostasis. The genetic variations within the PPARGC1A gene promoter region were scanned in 808 Chinese native bovines belonging to three cattle breeds and yaks. A total of 6 SNPs and one 4 bp insertion variation in the promoter region of the bovine PPARGC1A gene were identified: SNP -259 T>A, -301_-298insCTTT, -915 A>G, -1175 T>G, -1590 C>T, -1665 C>T and -1690 G>A, which are in the binding sites of some important transcription factors: sex-determining region Y (SRY), myeloid-specific zinc finger-1 (MZF-1) and octamer factor 1(Oct-1). It is expected that these polymorphisms may regulate PPARGC1A gene transcription and might have consequences at a regulatory level.
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spelling pubmed-40933952014-07-21 Polymorphisms in the Promoter Region of the Chinese Bovine PPARGC1A Gene Li, M. J. Liu, M. Liu, D. Lan, X. Y. Lei, C. Z. Yang, D. Y. Chen, H. Asian-Australas J Anim Sci Article The peroxisome proliferator-activated receptor gamma coactivator-1 alpha protein, encoded by the PPARGC1A gene, plays an important role in energy homeostasis. The genetic variations within the PPARGC1A gene promoter region were scanned in 808 Chinese native bovines belonging to three cattle breeds and yaks. A total of 6 SNPs and one 4 bp insertion variation in the promoter region of the bovine PPARGC1A gene were identified: SNP -259 T>A, -301_-298insCTTT, -915 A>G, -1175 T>G, -1590 C>T, -1665 C>T and -1690 G>A, which are in the binding sites of some important transcription factors: sex-determining region Y (SRY), myeloid-specific zinc finger-1 (MZF-1) and octamer factor 1(Oct-1). It is expected that these polymorphisms may regulate PPARGC1A gene transcription and might have consequences at a regulatory level. Asian-Australasian Association of Animal Production Societies (AAAP) and Korean Society of Animal Science and Technology (KSAST) 2013-04 /pmc/articles/PMC4093395/ /pubmed/25049813 http://dx.doi.org/10.5713/ajas.2012.12554 Text en Copyright © 2013 by Asian-Australasian Journal of Animal Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/ which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Li, M. J.
Liu, M.
Liu, D.
Lan, X. Y.
Lei, C. Z.
Yang, D. Y.
Chen, H.
Polymorphisms in the Promoter Region of the Chinese Bovine PPARGC1A Gene
title Polymorphisms in the Promoter Region of the Chinese Bovine PPARGC1A Gene
title_full Polymorphisms in the Promoter Region of the Chinese Bovine PPARGC1A Gene
title_fullStr Polymorphisms in the Promoter Region of the Chinese Bovine PPARGC1A Gene
title_full_unstemmed Polymorphisms in the Promoter Region of the Chinese Bovine PPARGC1A Gene
title_short Polymorphisms in the Promoter Region of the Chinese Bovine PPARGC1A Gene
title_sort polymorphisms in the promoter region of the chinese bovine ppargc1a gene
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093395/
https://www.ncbi.nlm.nih.gov/pubmed/25049813
http://dx.doi.org/10.5713/ajas.2012.12554
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