Discovery and Structure–Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors

[Image: see text] Novel substituted 2,3-dihydrobenzofuran-7-carboxamide (DHBF-7-carboxamide) and 2,3-dihydrobenzofuran-3(2H)-one-7-carboxamide (DHBF-3-one-7-carboxamide) derivatives were synthesized and evaluated as inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). A structure-based design strate...

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Detalles Bibliográficos
Autores principales: Patel, Maulik R., Bhatt, Aaditya, Steffen, Jamin D., Chergui, Adel, Murai, Junko, Pommier, Yves, Pascal, John M., Trombetta, Louis D., Fronczek, Frank R., Talele, Tanaji T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094269/
https://www.ncbi.nlm.nih.gov/pubmed/24922587
http://dx.doi.org/10.1021/jm5002502

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