RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53(abnormal) myeloma cells independently of the p53 pathway

BACKGROUND: The aim of this study was to evaluate the efficacy of the p53-reactivating drugs RITA and nutlin3a in killing myeloma cells. METHODS: A large cohort of myeloma cell lines (n = 32) and primary cells (n = 21) was used for this study. This cohort contained cell lines with various TP53 statu...

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Detalles Bibliográficos
Autores principales: Surget, Sylvanie, Descamps, Géraldine, Brosseau, Carole, Normant, Vincent, Maïga, Sophie, Gomez-Bougie, Patricia, Gouy-Colin, Nadège, Godon, Catherine, Béné, Marie C, Moreau, Philippe, Le Gouill, Steven, Amiot, Martine, Pellat-Deceunynck, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094448/
https://www.ncbi.nlm.nih.gov/pubmed/24927749
http://dx.doi.org/10.1186/1471-2407-14-437

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