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Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis
Previous studies have shown that Meis1 plays an important role in blood development and vascular homeostasis, and can induce blood cancers, such as leukemia. However, its role in epithelia remains largely unknown. Here, we uncover two roles for Meis1 in the epidermis: as a critical regulator of epid...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094504/ https://www.ncbi.nlm.nih.gov/pubmed/25013928 http://dx.doi.org/10.1371/journal.pone.0102111 |
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author | Okumura, Kazuhiro Saito, Megumi Isogai, Eriko Aoto, Yoshimasa Hachiya, Tsuyoshi Sakakibara, Yasubumi Katsuragi, Yoshinori Hirose, Satoshi Kominami, Ryo Goitsuka, Ryo Nakamura, Takuro Wakabayashi, Yuichi |
author_facet | Okumura, Kazuhiro Saito, Megumi Isogai, Eriko Aoto, Yoshimasa Hachiya, Tsuyoshi Sakakibara, Yasubumi Katsuragi, Yoshinori Hirose, Satoshi Kominami, Ryo Goitsuka, Ryo Nakamura, Takuro Wakabayashi, Yuichi |
author_sort | Okumura, Kazuhiro |
collection | PubMed |
description | Previous studies have shown that Meis1 plays an important role in blood development and vascular homeostasis, and can induce blood cancers, such as leukemia. However, its role in epithelia remains largely unknown. Here, we uncover two roles for Meis1 in the epidermis: as a critical regulator of epidermal homeostasis in normal tissues and as a proto-oncogenic factor in neoplastic tissues. In normal epidermis, we show that Meis1 is predominantly expressed in the bulge region of the hair follicles where multipotent adult stem cells reside, and that the number of these stem cells is reduced when Meis1 is deleted in the epidermal tissue of mice. Mice with epidermal deletion of Meis1 developed significantly fewer DMBA/TPA-induced benign and malignant tumors compared with wild-type mice, suggesting that Meis1 plays a role in both tumor development and malignant progression. This is consistent with the observation that Meis1 expression increases as tumors progress from benign papillomas to malignant carcinomas. Interestingly, we found that Meis1 localization was altered to neoplasia development. Instead of being localized to the stem cell region, Meis1 is localized to more differentiated cells in tumor tissues. These findings suggest that, during the transformation from normal to neoplastic tissues, a functional switch occurs in Meis1. |
format | Online Article Text |
id | pubmed-4094504 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40945042014-07-15 Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis Okumura, Kazuhiro Saito, Megumi Isogai, Eriko Aoto, Yoshimasa Hachiya, Tsuyoshi Sakakibara, Yasubumi Katsuragi, Yoshinori Hirose, Satoshi Kominami, Ryo Goitsuka, Ryo Nakamura, Takuro Wakabayashi, Yuichi PLoS One Research Article Previous studies have shown that Meis1 plays an important role in blood development and vascular homeostasis, and can induce blood cancers, such as leukemia. However, its role in epithelia remains largely unknown. Here, we uncover two roles for Meis1 in the epidermis: as a critical regulator of epidermal homeostasis in normal tissues and as a proto-oncogenic factor in neoplastic tissues. In normal epidermis, we show that Meis1 is predominantly expressed in the bulge region of the hair follicles where multipotent adult stem cells reside, and that the number of these stem cells is reduced when Meis1 is deleted in the epidermal tissue of mice. Mice with epidermal deletion of Meis1 developed significantly fewer DMBA/TPA-induced benign and malignant tumors compared with wild-type mice, suggesting that Meis1 plays a role in both tumor development and malignant progression. This is consistent with the observation that Meis1 expression increases as tumors progress from benign papillomas to malignant carcinomas. Interestingly, we found that Meis1 localization was altered to neoplasia development. Instead of being localized to the stem cell region, Meis1 is localized to more differentiated cells in tumor tissues. These findings suggest that, during the transformation from normal to neoplastic tissues, a functional switch occurs in Meis1. Public Library of Science 2014-07-11 /pmc/articles/PMC4094504/ /pubmed/25013928 http://dx.doi.org/10.1371/journal.pone.0102111 Text en © 2014 Okumura et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Okumura, Kazuhiro Saito, Megumi Isogai, Eriko Aoto, Yoshimasa Hachiya, Tsuyoshi Sakakibara, Yasubumi Katsuragi, Yoshinori Hirose, Satoshi Kominami, Ryo Goitsuka, Ryo Nakamura, Takuro Wakabayashi, Yuichi Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis |
title | Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis |
title_full | Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis |
title_fullStr | Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis |
title_full_unstemmed | Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis |
title_short | Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis |
title_sort | meis1 regulates epidermal stem cells and is required for skin tumorigenesis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094504/ https://www.ncbi.nlm.nih.gov/pubmed/25013928 http://dx.doi.org/10.1371/journal.pone.0102111 |
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