Cargando…

Loss of Sirt1 Function Improves Intestinal Anti-Bacterial Defense and Protects from Colitis-Induced Colorectal Cancer

Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD(+)-dependent histone deacetylase SIRT1 in the control of anti-bacterial defense. Mice with an intestinal specific...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lo Sasso, Giuseppe, Ryu, Dongryeol, Mouchiroud, Laurent, Fernando, Samodha C., Anderson, Christopher L., Katsyuba, Elena, Piersigilli, Alessandra, Hottiger, Michael O., Schoonjans, Kristina, Auwerx, Johan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094521/ https://www.ncbi.nlm.nih.gov/pubmed/25013930 http://dx.doi.org/10.1371/journal.pone.0102495

Ejemplares similares

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis
por: Lo Sasso, Giuseppe, et al.
Publicado: (2014)

Mitonuclear protein imbalance as a conserved longevity mechanism
por: Houtkooper, Riekelt H., et al.
Publicado: (2013)

Metabolic Characterization of a Sirt5 deficient mouse model
por: Yu, Jiujiu, et al.
Publicado: (2013)

Automated Platform for Long-Term Culture and High-Content Phenotyping of Single C. elegans Worms
por: Atakan, H. B., et al.
Publicado: (2019)

De novo NAD(+) synthesis enhances mitochondrial function and improves health
por: Katsyuba, Elena, et al.
Publicado: (2018)

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer
por: Xu, Pan, et al.
Publicado: (2016)

Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment
por: Wang, Xu, et al.
Publicado: (2015)

The Sirt1 activator SRT3025 provides atheroprotection in Apoe(−/−) mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
por: Miranda, Melroy X., et al.
Publicado: (2015)

Tetracycline-induced mitohormesis mediates disease tolerance against influenza
por: Mottis, Adrienne, et al.
Publicado: (2022)

Activation of the peroxisome proliferator-activated receptor α protects against myocardial ischaemic injury and improves endothelial vasodilatation
por: Tabernero, Antonia, et al.
Publicado: (2002)

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis
por: Fernandez-Marcos, Pablo J., et al.
Publicado: (2012)

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice
por: Gariani, Karim, et al.
Publicado: (2015)

Interference between PARPs and SIRT1: a novel approach to healthy ageing?
por: CantÓ, Carles, et al.
Publicado: (2011)

GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression
por: Addicks, Gregory C., et al.
Publicado: (2022)

An Evolutionarily Conserved Role for the Aryl Hydrocarbon Receptor in the Regulation of Movement
por: Williams, Evan G., et al.
Publicado: (2014)

Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models
por: Cornaglia, Matteo, et al.
Publicado: (2016)

Label-free three-dimensional imaging of Caenorhabditis elegans with visible optical coherence microscopy
por: Coquoz, Séverine, et al.
Publicado: (2017)

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
por: Harach, Taoufiq, et al.
Publicado: (2012)

Identifying gene function and module connections by the integration of multispecies expression compendia
por: Li, Hao, et al.
Publicado: (2019)

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging
por: Cornaglia, Matteo, et al.
Publicado: (2015)

Reversible and long-term immobilization in a hydrogel-microbead matrix for high-resolution imaging of Caenorhabditis elegans and other small organisms
por: Dong, Li, et al.
Publicado: (2018)

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections
por: Ciarlo, Eleonora, et al.
Publicado: (2017)

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans
por: Andreux, Pénélope A., et al.
Publicado: (2014)

Microfluidics-enabled phenotyping of a whole population of C. elegans worms over their embryonic and post-embryonic development at single-organism resolution
por: Letizia, Maria Cristina, et al.
Publicado: (2018)

NR5A2 Regulates Lhb and Fshb Transcription in Gonadotrope-Like Cells In Vitro, but Is Dispensable for Gonadotropin Synthesis and Fertility In Vivo
por: Fortin, Jérôme, et al.
Publicado: (2013)

Type 5 adenylyl cyclase disruption leads to enhanced exercise performance
por: Vatner, Dorothy E., et al.
Publicado: (2015)

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14
por: Vatner, Dorothy E., et al.
Publicado: (2018)

Dietary Fiber Is Essential to Maintain Intestinal Size, L-Cell Secretion, and Intestinal Integrity in Mice
por: Hunt, Jenna Elizabeth, et al.
Publicado: (2021)

Impact of the Dual Deletion of the Mitochondrial Sirtuins SIRT3 and SIRT5 on Anti-microbial Host Defenses
por: Heinonen, Tytti, et al.
Publicado: (2019)

ARTD1-induced poly-ADP-ribose formation enhances PPARγ ligand binding and co-factor exchange
por: Lehmann, Mareike, et al.
Publicado: (2015)

The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine
por: Mueller, Matthias, et al.
Publicado: (2006)

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs
por: Yildiz, Ece, et al.
Publicado: (2023)

Attenuation of Colon Inflammation through Activators of the Retinoid X Receptor (Rxr)/Peroxisome Proliferator–Activated Receptor γ (Pparγ) Heterodimer: A Basis for New Therapeutic Strategies
por: Desreumaux, Pierre, et al.
Publicado: (2001)

Chitosan Oligosaccharides Alleviate Colitis by Regulating Intestinal Microbiota and PPARγ/SIRT1-Mediated NF-κB Pathway
por: Guo, Congcong, et al.
Publicado: (2022)

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans
por: Li, Terytty Yang, et al.
Publicado: (2022)

The metabolic footprint of aging in mice
por: Houtkooper, Riekelt H., et al.
Publicado: (2011)

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
por: Sorrentino, Vincenzo, et al.
Publicado: (2017)

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population
por: Li, Xiaoxu, et al.
Publicado: (2023)

NCoR1 Protects Mice From Dextran Sodium Sulfate–Induced Colitis by Guarding Colonic Crypt Cells From Luminal Insult
por: Mennillo, Elvira, et al.
Publicado: (2020)

The Intestinal Immune Defense System in Insects
por: Zeng, Tian, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_81p0rh5uasajdtcdnhs3m3fj2h