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The association between retinal vascular geometry changes and diabetic retinopathy and their role in prediction of progression – an exploratory study

BACKGROUND: The study describes the relationship of retinal vascular geometry (RVG) to severity of diabetic retinopathy (DR), and its predictive role for subsequent development of proliferative diabetic retinopathy (PDR). METHODS: The research project comprises of two stages. Firstly, a comparative...

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Autores principales: Habib, Maged S, Al-Diri, Bashir, Hunter, Andrew, Steel, David HW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094636/
https://www.ncbi.nlm.nih.gov/pubmed/25001248
http://dx.doi.org/10.1186/1471-2415-14-89
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author Habib, Maged S
Al-Diri, Bashir
Hunter, Andrew
Steel, David HW
author_facet Habib, Maged S
Al-Diri, Bashir
Hunter, Andrew
Steel, David HW
author_sort Habib, Maged S
collection PubMed
description BACKGROUND: The study describes the relationship of retinal vascular geometry (RVG) to severity of diabetic retinopathy (DR), and its predictive role for subsequent development of proliferative diabetic retinopathy (PDR). METHODS: The research project comprises of two stages. Firstly, a comparative study of diabetic patients with different grades of DR. (No DR: Minimal non-proliferative DR: Severe non-proliferative DR: PDR) (10:10: 12: 19). Analysed RVG features including vascular widths and branching angles were compared between patient cohorts. A preliminary statistical model for determination of the retinopathy grade of patients, using these features, is presented. Secondly, in a longitudinal predictive study, RVG features were analysed for diabetic patients with progressive DR over 7 years. RVG at baseline was examined to determine risk for subsequent PDR development. RESULTS: In the comparative study, increased DR severity was associated with gradual vascular dilatation (p = 0.000), and widening of the bifurcating angle (p = 0.000) with increase in smaller-child-vessel branching angle (p = 0.027). Type 2 diabetes and increased diabetes duration were associated with increased vascular width (p = <0.05 In the predictive study, at baseline, reduced small-child vascular width (OR = 0.73 (95% CI 0.58-0.92)), was predictive of future progression to PDR. CONCLUSIONS: The study findings suggest that RVG alterations can act as novel markers indicative of progression of DR severity and establishment of PDR. RVG may also have a potential predictive role in determining the risk of future retinopathy progression.
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spelling pubmed-40946362014-07-13 The association between retinal vascular geometry changes and diabetic retinopathy and their role in prediction of progression – an exploratory study Habib, Maged S Al-Diri, Bashir Hunter, Andrew Steel, David HW BMC Ophthalmol Research Article BACKGROUND: The study describes the relationship of retinal vascular geometry (RVG) to severity of diabetic retinopathy (DR), and its predictive role for subsequent development of proliferative diabetic retinopathy (PDR). METHODS: The research project comprises of two stages. Firstly, a comparative study of diabetic patients with different grades of DR. (No DR: Minimal non-proliferative DR: Severe non-proliferative DR: PDR) (10:10: 12: 19). Analysed RVG features including vascular widths and branching angles were compared between patient cohorts. A preliminary statistical model for determination of the retinopathy grade of patients, using these features, is presented. Secondly, in a longitudinal predictive study, RVG features were analysed for diabetic patients with progressive DR over 7 years. RVG at baseline was examined to determine risk for subsequent PDR development. RESULTS: In the comparative study, increased DR severity was associated with gradual vascular dilatation (p = 0.000), and widening of the bifurcating angle (p = 0.000) with increase in smaller-child-vessel branching angle (p = 0.027). Type 2 diabetes and increased diabetes duration were associated with increased vascular width (p = <0.05 In the predictive study, at baseline, reduced small-child vascular width (OR = 0.73 (95% CI 0.58-0.92)), was predictive of future progression to PDR. CONCLUSIONS: The study findings suggest that RVG alterations can act as novel markers indicative of progression of DR severity and establishment of PDR. RVG may also have a potential predictive role in determining the risk of future retinopathy progression. BioMed Central 2014-07-07 /pmc/articles/PMC4094636/ /pubmed/25001248 http://dx.doi.org/10.1186/1471-2415-14-89 Text en Copyright © 2014 Habib et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Habib, Maged S
Al-Diri, Bashir
Hunter, Andrew
Steel, David HW
The association between retinal vascular geometry changes and diabetic retinopathy and their role in prediction of progression – an exploratory study
title The association between retinal vascular geometry changes and diabetic retinopathy and their role in prediction of progression – an exploratory study
title_full The association between retinal vascular geometry changes and diabetic retinopathy and their role in prediction of progression – an exploratory study
title_fullStr The association between retinal vascular geometry changes and diabetic retinopathy and their role in prediction of progression – an exploratory study
title_full_unstemmed The association between retinal vascular geometry changes and diabetic retinopathy and their role in prediction of progression – an exploratory study
title_short The association between retinal vascular geometry changes and diabetic retinopathy and their role in prediction of progression – an exploratory study
title_sort association between retinal vascular geometry changes and diabetic retinopathy and their role in prediction of progression – an exploratory study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094636/
https://www.ncbi.nlm.nih.gov/pubmed/25001248
http://dx.doi.org/10.1186/1471-2415-14-89
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