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Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer

Ovarian cancer is the most lethal gynecologic malignancy among women worldwide and is presumed to result from the presence of ovarian cancer stem cells. To overcome the limitation of current anticancer agents, another anticancer strategy is necessary to effectively target cancer stem cells in ovaria...

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Detalles Bibliográficos
Autores principales: Kim, Tae Hun, Suh, Dong Hoon, Kim, Mi-Kyung, Song, Yong Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094711/
https://www.ncbi.nlm.nih.gov/pubmed/25050322
http://dx.doi.org/10.1155/2014/132702
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author Kim, Tae Hun
Suh, Dong Hoon
Kim, Mi-Kyung
Song, Yong Sang
author_facet Kim, Tae Hun
Suh, Dong Hoon
Kim, Mi-Kyung
Song, Yong Sang
author_sort Kim, Tae Hun
collection PubMed
description Ovarian cancer is the most lethal gynecologic malignancy among women worldwide and is presumed to result from the presence of ovarian cancer stem cells. To overcome the limitation of current anticancer agents, another anticancer strategy is necessary to effectively target cancer stem cells in ovarian cancer. In many types of malignancies, including ovarian cancer, metformin, one of the most popular antidiabetic drugs, has been demonstrated to exhibit chemopreventive and anticancer efficacy with respect to incidence and overall survival rates. Thus, the metabolic reprogramming of cancer and cancer stem cells driven by genetic alterations during carcinogenesis and cancer progression could be therapeutically targeted. In this review, the potential efficacy and anticancer mechanisms of metformin against ovarian cancer stem cells will be discussed.
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spelling pubmed-40947112014-07-21 Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer Kim, Tae Hun Suh, Dong Hoon Kim, Mi-Kyung Song, Yong Sang Biomed Res Int Review Article Ovarian cancer is the most lethal gynecologic malignancy among women worldwide and is presumed to result from the presence of ovarian cancer stem cells. To overcome the limitation of current anticancer agents, another anticancer strategy is necessary to effectively target cancer stem cells in ovarian cancer. In many types of malignancies, including ovarian cancer, metformin, one of the most popular antidiabetic drugs, has been demonstrated to exhibit chemopreventive and anticancer efficacy with respect to incidence and overall survival rates. Thus, the metabolic reprogramming of cancer and cancer stem cells driven by genetic alterations during carcinogenesis and cancer progression could be therapeutically targeted. In this review, the potential efficacy and anticancer mechanisms of metformin against ovarian cancer stem cells will be discussed. Hindawi Publishing Corporation 2014 2014-06-24 /pmc/articles/PMC4094711/ /pubmed/25050322 http://dx.doi.org/10.1155/2014/132702 Text en Copyright © 2014 Tae Hun Kim et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kim, Tae Hun
Suh, Dong Hoon
Kim, Mi-Kyung
Song, Yong Sang
Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer
title Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer
title_full Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer
title_fullStr Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer
title_full_unstemmed Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer
title_short Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism: Special Considerations on Ovarian Cancer
title_sort metformin against cancer stem cells through the modulation of energy metabolism: special considerations on ovarian cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094711/
https://www.ncbi.nlm.nih.gov/pubmed/25050322
http://dx.doi.org/10.1155/2014/132702
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