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Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer
This study aimed to investigate the impact of underweight status on the prognosis of advanced-stage ovarian cancer. A total of 360 patients with stage III-IV epithelial ovarian cancer were enrolled and divided into three groups by body mass indexes (BMIs): underweight (BMI < 18.5 kg/m(2)); normal...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094724/ https://www.ncbi.nlm.nih.gov/pubmed/25050383 http://dx.doi.org/10.1155/2014/349546 |
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author | Kim, Se Ik Kim, Hee Seung Kim, Tae Hun Suh, Dong Hoon Kim, Kidong No, Jae Hong Chung, Hyun Hoon Kim, Yong Beom Song, Yong Sang |
author_facet | Kim, Se Ik Kim, Hee Seung Kim, Tae Hun Suh, Dong Hoon Kim, Kidong No, Jae Hong Chung, Hyun Hoon Kim, Yong Beom Song, Yong Sang |
author_sort | Kim, Se Ik |
collection | PubMed |
description | This study aimed to investigate the impact of underweight status on the prognosis of advanced-stage ovarian cancer. A total of 360 patients with stage III-IV epithelial ovarian cancer were enrolled and divided into three groups by body mass indexes (BMIs): underweight (BMI < 18.5 kg/m(2)); normal weight to overweight (18.5 kg/m(2) BMI < 27.5 kg/m(2)); obesity (BMI ≥ 27.5 kg/m(2)). Progression-free survival (PFS), overall survival (OS), CA-125, and neutrophil to lymphocyte ratio (NLR) as a marker reflecting host inflammation and immunity were compared among the three groups according to the three treatment times: at diagnosis; after surgery; and after treatment. Only underweight status after treatment was associated with poor OS in comparison with normal weight to overweight or obesity (mean value, 44.9 versus 78.8 or 67.4 months; P = 0.05); it was also an unfavorable factor for OS (adjusted HR, 2.29; 95% CI, 1.08–4.85). Furthermore, NLR was higher in patients with underweight than in those with obesity after treatment (median value, 2.15 versus 1.47; P = 0.03), in spite of no difference in CA-125 among the three groups at the three treatment times. In conclusion, underweight status after treatment may be a poor prognostic factor in patients with advanced-stage ovarian cancer, which accompanies increased host inflammation and decreased immunity. |
format | Online Article Text |
id | pubmed-4094724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40947242014-07-21 Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer Kim, Se Ik Kim, Hee Seung Kim, Tae Hun Suh, Dong Hoon Kim, Kidong No, Jae Hong Chung, Hyun Hoon Kim, Yong Beom Song, Yong Sang J Immunol Res Research Article This study aimed to investigate the impact of underweight status on the prognosis of advanced-stage ovarian cancer. A total of 360 patients with stage III-IV epithelial ovarian cancer were enrolled and divided into three groups by body mass indexes (BMIs): underweight (BMI < 18.5 kg/m(2)); normal weight to overweight (18.5 kg/m(2) BMI < 27.5 kg/m(2)); obesity (BMI ≥ 27.5 kg/m(2)). Progression-free survival (PFS), overall survival (OS), CA-125, and neutrophil to lymphocyte ratio (NLR) as a marker reflecting host inflammation and immunity were compared among the three groups according to the three treatment times: at diagnosis; after surgery; and after treatment. Only underweight status after treatment was associated with poor OS in comparison with normal weight to overweight or obesity (mean value, 44.9 versus 78.8 or 67.4 months; P = 0.05); it was also an unfavorable factor for OS (adjusted HR, 2.29; 95% CI, 1.08–4.85). Furthermore, NLR was higher in patients with underweight than in those with obesity after treatment (median value, 2.15 versus 1.47; P = 0.03), in spite of no difference in CA-125 among the three groups at the three treatment times. In conclusion, underweight status after treatment may be a poor prognostic factor in patients with advanced-stage ovarian cancer, which accompanies increased host inflammation and decreased immunity. Hindawi Publishing Corporation 2014 2014-06-24 /pmc/articles/PMC4094724/ /pubmed/25050383 http://dx.doi.org/10.1155/2014/349546 Text en Copyright © 2014 Se Ik Kim et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kim, Se Ik Kim, Hee Seung Kim, Tae Hun Suh, Dong Hoon Kim, Kidong No, Jae Hong Chung, Hyun Hoon Kim, Yong Beom Song, Yong Sang Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer |
title | Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer |
title_full | Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer |
title_fullStr | Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer |
title_full_unstemmed | Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer |
title_short | Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer |
title_sort | impact of underweight after treatment on prognosis of advanced-stage ovarian cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094724/ https://www.ncbi.nlm.nih.gov/pubmed/25050383 http://dx.doi.org/10.1155/2014/349546 |
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