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Osteoporosis, Fractures, and Diabetes

It is well established that osteoporosis and diabetes are prevalent diseases with significant associated morbidity and mortality. Patients with diabetes mellitus have an increased risk of bone fractures. In type 1 diabetes, the risk is increased by ∼6 times and is due to low bone mass. Despite incre...

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Detalles Bibliográficos
Autores principales: Jackuliak, Peter, Payer, Juraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094869/
https://www.ncbi.nlm.nih.gov/pubmed/25050121
http://dx.doi.org/10.1155/2014/820615
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author Jackuliak, Peter
Payer, Juraj
author_facet Jackuliak, Peter
Payer, Juraj
author_sort Jackuliak, Peter
collection PubMed
description It is well established that osteoporosis and diabetes are prevalent diseases with significant associated morbidity and mortality. Patients with diabetes mellitus have an increased risk of bone fractures. In type 1 diabetes, the risk is increased by ∼6 times and is due to low bone mass. Despite increased bone mineral density (BMD), in patients with type 2 diabetes the risk is increased (which is about twice the risk in the general population) due to the inferior quality of bone. Bone fragility in type 2 diabetes, which is not reflected by bone mineral density, depends on bone quality deterioration rather than bone mass reduction. Thus, surrogate markers and examination methods are needed to replace the insensitivity of BMD in assessing fracture risks of T2DM patients. One of these methods can be trabecular bone score. The aim of the paper is to present the present state of scientific knowledge about the osteoporosis risk in diabetic patient. The review also discusses the possibility of problematic using the study conclusions in real clinical practice.
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spelling pubmed-40948692014-07-21 Osteoporosis, Fractures, and Diabetes Jackuliak, Peter Payer, Juraj Int J Endocrinol Review Article It is well established that osteoporosis and diabetes are prevalent diseases with significant associated morbidity and mortality. Patients with diabetes mellitus have an increased risk of bone fractures. In type 1 diabetes, the risk is increased by ∼6 times and is due to low bone mass. Despite increased bone mineral density (BMD), in patients with type 2 diabetes the risk is increased (which is about twice the risk in the general population) due to the inferior quality of bone. Bone fragility in type 2 diabetes, which is not reflected by bone mineral density, depends on bone quality deterioration rather than bone mass reduction. Thus, surrogate markers and examination methods are needed to replace the insensitivity of BMD in assessing fracture risks of T2DM patients. One of these methods can be trabecular bone score. The aim of the paper is to present the present state of scientific knowledge about the osteoporosis risk in diabetic patient. The review also discusses the possibility of problematic using the study conclusions in real clinical practice. Hindawi Publishing Corporation 2014 2014-06-23 /pmc/articles/PMC4094869/ /pubmed/25050121 http://dx.doi.org/10.1155/2014/820615 Text en Copyright © 2014 P. Jackuliak and J. Payer. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jackuliak, Peter
Payer, Juraj
Osteoporosis, Fractures, and Diabetes
title Osteoporosis, Fractures, and Diabetes
title_full Osteoporosis, Fractures, and Diabetes
title_fullStr Osteoporosis, Fractures, and Diabetes
title_full_unstemmed Osteoporosis, Fractures, and Diabetes
title_short Osteoporosis, Fractures, and Diabetes
title_sort osteoporosis, fractures, and diabetes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094869/
https://www.ncbi.nlm.nih.gov/pubmed/25050121
http://dx.doi.org/10.1155/2014/820615
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