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Osteoporosis, Fractures, and Diabetes
It is well established that osteoporosis and diabetes are prevalent diseases with significant associated morbidity and mortality. Patients with diabetes mellitus have an increased risk of bone fractures. In type 1 diabetes, the risk is increased by ∼6 times and is due to low bone mass. Despite incre...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094869/ https://www.ncbi.nlm.nih.gov/pubmed/25050121 http://dx.doi.org/10.1155/2014/820615 |
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author | Jackuliak, Peter Payer, Juraj |
author_facet | Jackuliak, Peter Payer, Juraj |
author_sort | Jackuliak, Peter |
collection | PubMed |
description | It is well established that osteoporosis and diabetes are prevalent diseases with significant associated morbidity and mortality. Patients with diabetes mellitus have an increased risk of bone fractures. In type 1 diabetes, the risk is increased by ∼6 times and is due to low bone mass. Despite increased bone mineral density (BMD), in patients with type 2 diabetes the risk is increased (which is about twice the risk in the general population) due to the inferior quality of bone. Bone fragility in type 2 diabetes, which is not reflected by bone mineral density, depends on bone quality deterioration rather than bone mass reduction. Thus, surrogate markers and examination methods are needed to replace the insensitivity of BMD in assessing fracture risks of T2DM patients. One of these methods can be trabecular bone score. The aim of the paper is to present the present state of scientific knowledge about the osteoporosis risk in diabetic patient. The review also discusses the possibility of problematic using the study conclusions in real clinical practice. |
format | Online Article Text |
id | pubmed-4094869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40948692014-07-21 Osteoporosis, Fractures, and Diabetes Jackuliak, Peter Payer, Juraj Int J Endocrinol Review Article It is well established that osteoporosis and diabetes are prevalent diseases with significant associated morbidity and mortality. Patients with diabetes mellitus have an increased risk of bone fractures. In type 1 diabetes, the risk is increased by ∼6 times and is due to low bone mass. Despite increased bone mineral density (BMD), in patients with type 2 diabetes the risk is increased (which is about twice the risk in the general population) due to the inferior quality of bone. Bone fragility in type 2 diabetes, which is not reflected by bone mineral density, depends on bone quality deterioration rather than bone mass reduction. Thus, surrogate markers and examination methods are needed to replace the insensitivity of BMD in assessing fracture risks of T2DM patients. One of these methods can be trabecular bone score. The aim of the paper is to present the present state of scientific knowledge about the osteoporosis risk in diabetic patient. The review also discusses the possibility of problematic using the study conclusions in real clinical practice. Hindawi Publishing Corporation 2014 2014-06-23 /pmc/articles/PMC4094869/ /pubmed/25050121 http://dx.doi.org/10.1155/2014/820615 Text en Copyright © 2014 P. Jackuliak and J. Payer. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Jackuliak, Peter Payer, Juraj Osteoporosis, Fractures, and Diabetes |
title | Osteoporosis, Fractures, and Diabetes |
title_full | Osteoporosis, Fractures, and Diabetes |
title_fullStr | Osteoporosis, Fractures, and Diabetes |
title_full_unstemmed | Osteoporosis, Fractures, and Diabetes |
title_short | Osteoporosis, Fractures, and Diabetes |
title_sort | osteoporosis, fractures, and diabetes |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094869/ https://www.ncbi.nlm.nih.gov/pubmed/25050121 http://dx.doi.org/10.1155/2014/820615 |
work_keys_str_mv | AT jackuliakpeter osteoporosisfracturesanddiabetes AT payerjuraj osteoporosisfracturesanddiabetes |