Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples

BACKGROUND: Since tumor suppressor gene function may be lost through hypermethylation, we assessed whether the demethylating agent decitabine could increase tumor suppressor gene expression clinically. For fragile histidine triad (FHIT), WW domain-containing oxidoreductase (WWOX), fused in sarcoma-1...

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Detalles Bibliográficos
Autores principales: Stewart, David J, Nunez, Maria I, Jelinek, Jaroslav, Hong, David, Gupta, Sanjay, Aldaz, Marcelo, Issa, Jean-Pierre, Kurzrock, Razelle, Wistuba, Ignacio I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094901/
https://www.ncbi.nlm.nih.gov/pubmed/25024751
http://dx.doi.org/10.1186/1868-7083-6-13

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