Cargando…

Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum

BACKGROUND: In view of the need to continuously feed the pipeline with new anti-malarial agents adapted to differentiated and more stringent target product profiles (e.g., new modes of action, transmission-blocking activity or long-duration chemo-protection), a chemical library consisting of more th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Avery, Vicky M, Bashyam, Sridevi, Burrows, Jeremy N, Duffy, Sandra, Papadatos, George, Puthukkuti, Shyni, Sambandan, Yuvaraj, Singh, Shivendra, Spangenberg, Thomas, Waterson, David, Willis, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094919/ https://www.ncbi.nlm.nih.gov/pubmed/24886460 http://dx.doi.org/10.1186/1475-2875-13-190

Ejemplares similares

Identification of inhibitors of Plasmodium falciparum gametocyte development
por: Duffy, Sandra, et al.
Publicado: (2013)

Screening a protein kinase inhibitor library against Plasmodium falciparum
por: Hallyburton, Irene, et al.
Publicado: (2017)

Discovery of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A pathway
por: Fletcher, Sabine, et al.
Publicado: (2014)

Plasmodium falciparum in vitro continuous culture conditions: A comparison of parasite susceptibility and tolerance to anti-malarial drugs throughout the asexual intra-erythrocytic life cycle
por: Duffy, Sandra, et al.
Publicado: (2017)

Naturally Acquired Kelch13 Mutations in Plasmodium falciparum Strains Modulate In Vitro Ring-Stage Artemisinin-Based Drug Tolerance and Parasite Survival in Response to Hyperoxia
por: Duffy, Sandra, et al.
Publicado: (2022)

Chemical genetics of Plasmodium falciparum
por: Guiguemde, W. Armand, et al.
Publicado: (2010)

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome
por: Xie, Stanley C., et al.
Publicado: (2018)

A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway
por: Fletcher, Sabine, et al.
Publicado: (2014)

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity
por: Kokkonda, Sreekanth, et al.
Publicado: (2018)

Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway
por: Fletcher, Sabine, et al.
Publicado: (2016)

A library of functional recombinant Plasmodium falciparum merozoite surface proteins
por: Crosnier, Cecile, et al.
Publicado: (2010)

Impact of library input on the hit discovery rate in DNA-encoded chemical library selections
por: Puglioli, Sara, et al.
Publicado: (2023)

The need to compare: assessing the level of agreement of three high-throughput assays against Plasmodium falciparum mature gametocytes
por: Lucantoni, Leonardo, et al.
Publicado: (2017)

Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model
por: Tipsuwan, Wachiraporn, et al.
Publicado: (2011)

Construction and use of Plasmodium falciparum phage display libraries to identify host parasite interactions
por: Lauterbach, Sonja B, et al.
Publicado: (2003)

Using a genome-scale metabolic network model to elucidate the mechanism of chloroquine action in Plasmodium falciparum
por: Tewari, Shivendra G., et al.
Publicado: (2017)

Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages
por: Weidner, Thomas, et al.
Publicado: (2017)

Metabolic adjustments of blood-stage Plasmodium falciparum in response to sublethal pyrazoleamide exposure
por: Tewari, Shivendra G., et al.
Publicado: (2022)

Metabolic changes accompanying the loss of fumarate hydratase and malate–quinone oxidoreductase in the asexual blood stage of Plasmodium falciparum
por: Rajaram, Krithika, et al.
Publicado: (2022)

Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library
por: Nurkanto, Arif, et al.
Publicado: (2022)

Towards a comprehensive Plasmodium falciparum merozoite cell surface and secreted recombinant protein library
por: Zenonos, Zenon A, et al.
Publicado: (2014)

Pyrazoleamide compounds are potent antimalarials that target Na(+) homeostasis in intraerythrocytic Plasmodium falciparum
por: Vaidya, Akhil B., et al.
Publicado: (2014)

Antimalarial drug discovery – the path towards eradication
por: BURROWS, JEREMY N, et al.
Publicado: (2014)

Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax
por: Ferreira, Letícia Tiburcio, et al.
Publicado: (2020)

Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability
por: Tewari, Shivendra G., et al.
Publicado: (2019)

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors
por: Deng, Xiaoyi, et al.
Publicado: (2014)

Novel 2-Phenoxyanilide Congeners Derived from a Hit Structure of the TCAMS: Synthesis and Evaluation of Their in Vitro Activity against Plasmodium falciparum
por: Weidner, Thomas, et al.
Publicado: (2016)

Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum
por: Le Manach, Claire, et al.
Publicado: (2013)

Identification of Plasmodium falciparum Mitochondrial Malate: Quinone Oxidoreductase Inhibitors from the Pathogen Box
por: Wang, Xinying, et al.
Publicado: (2019)

A simple and predictive phenotypic High Content Imaging assay for Plasmodium falciparum mature gametocytes to identify malaria transmission blocking compounds
por: Lucantoni, Leonardo, et al.
Publicado: (2015)

Gametocytogenesis : the puberty of Plasmodium falciparum
por: Talman, Arthur M, et al.
Publicado: (2004)

Gametocytes of Plasmodium falciparum in the megakaryocytes
por: Chandra, Harish, et al.
Publicado: (2011)

Plasmodium falciparum in Ancient Egypt
por: Nerlich, Andreas G., et al.
Publicado: (2008)

Telomeric Heterochromatin in Plasmodium falciparum
por: Hernandez-Rivas, Rosaura, et al.
Publicado: (2010)

Detectability of Plasmodium falciparum clones
por: Bretscher, Michael T, et al.
Publicado: (2010)

The duration of Plasmodium falciparum infections
por: Ashley, Elizabeth A, et al.
Publicado: (2014)

Protein Sorting in Plasmodium Falciparum
por: Mayer, D.C. Ghislaine
Publicado: (2021)

Calorimeter fast simulation based on hit libraries LHCb Gauss framework
por: Rama, Matteo, et al.
Publicado: (2019)

Opportunities for Expanding Encoded Chemical Diversification and Improving Hit Enrichment in mRNA‐Displayed Peptide Libraries
por: Melsen, Paddy R. A., et al.
Publicado: (2022)

Genetic diversity of Plasmodium vivax and Plasmodium falciparum in Honduras
por: Lopez, Ana Cecilia, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_7eee64et8u3bcp029tb5eavipm