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Optimal Control of HIV/AIDS in the Workplace in the Presence of Careless Individuals

A nonlinear dynamical system is proposed and qualitatively analyzed to study the dynamics of HIV/AIDS in the workplace. The disease-free equilibrium point of the model is shown to be locally asymptotically stable if the basic reproductive number, ℛ (0), is less than unity and the model is shown to e...

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Detalles Bibliográficos
Autores principales: Seidu, Baba, Makinde, Oluwole D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095671/
https://www.ncbi.nlm.nih.gov/pubmed/25097663
http://dx.doi.org/10.1155/2014/831506
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author Seidu, Baba
Makinde, Oluwole D.
author_facet Seidu, Baba
Makinde, Oluwole D.
author_sort Seidu, Baba
collection PubMed
description A nonlinear dynamical system is proposed and qualitatively analyzed to study the dynamics of HIV/AIDS in the workplace. The disease-free equilibrium point of the model is shown to be locally asymptotically stable if the basic reproductive number, ℛ (0), is less than unity and the model is shown to exhibit a unique endemic equilibrium when the basic reproductive number is greater than unity. It is shown that, in the absence of recruitment of infectives, the disease is eradicated when ℛ (0) < 1, whiles the disease is shown to persist in the presence of recruitment of infected persons. The basic model is extended to include control efforts aimed at reducing infection, irresponsibility, and nonproductivity at the workplace. This leads to an optimal control problem which is qualitatively analyzed using Pontryagin's Maximum Principle (PMP). Numerical simulation of the resulting optimal control problem is carried out to gain quantitative insights into the implications of the model. The simulation reveals that a multifaceted approach to the fight against the disease is more effective than single control strategies.
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spelling pubmed-40956712014-08-05 Optimal Control of HIV/AIDS in the Workplace in the Presence of Careless Individuals Seidu, Baba Makinde, Oluwole D. Comput Math Methods Med Research Article A nonlinear dynamical system is proposed and qualitatively analyzed to study the dynamics of HIV/AIDS in the workplace. The disease-free equilibrium point of the model is shown to be locally asymptotically stable if the basic reproductive number, ℛ (0), is less than unity and the model is shown to exhibit a unique endemic equilibrium when the basic reproductive number is greater than unity. It is shown that, in the absence of recruitment of infectives, the disease is eradicated when ℛ (0) < 1, whiles the disease is shown to persist in the presence of recruitment of infected persons. The basic model is extended to include control efforts aimed at reducing infection, irresponsibility, and nonproductivity at the workplace. This leads to an optimal control problem which is qualitatively analyzed using Pontryagin's Maximum Principle (PMP). Numerical simulation of the resulting optimal control problem is carried out to gain quantitative insights into the implications of the model. The simulation reveals that a multifaceted approach to the fight against the disease is more effective than single control strategies. Hindawi Publishing Corporation 2014 2014-06-26 /pmc/articles/PMC4095671/ /pubmed/25097663 http://dx.doi.org/10.1155/2014/831506 Text en Copyright © 2014 B. Seidu and O. D. Makinde. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Seidu, Baba
Makinde, Oluwole D.
Optimal Control of HIV/AIDS in the Workplace in the Presence of Careless Individuals
title Optimal Control of HIV/AIDS in the Workplace in the Presence of Careless Individuals
title_full Optimal Control of HIV/AIDS in the Workplace in the Presence of Careless Individuals
title_fullStr Optimal Control of HIV/AIDS in the Workplace in the Presence of Careless Individuals
title_full_unstemmed Optimal Control of HIV/AIDS in the Workplace in the Presence of Careless Individuals
title_short Optimal Control of HIV/AIDS in the Workplace in the Presence of Careless Individuals
title_sort optimal control of hiv/aids in the workplace in the presence of careless individuals
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095671/
https://www.ncbi.nlm.nih.gov/pubmed/25097663
http://dx.doi.org/10.1155/2014/831506
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