Cargando…
Undecaprenyl Diphosphate Synthase Inhibitors: Antibacterial Drug Leads
[Image: see text] There is a significant need for new antibiotics due to the rise in drug resistance. Drugs such as methicillin and vancomycin target bacterial cell wall biosynthesis, but methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) have now arisen an...
Autores principales: | Sinko, William, Wang, Yang, Zhu, Wei, Zhang, Yonghui, Feixas, Ferran, Cox, Courtney L., Mitchell, Douglas A., Oldfield, Eric, McCammon, J. Andrew |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096218/ https://www.ncbi.nlm.nih.gov/pubmed/24827744 http://dx.doi.org/10.1021/jm5004649 |
Ejemplares similares
-
Applying Molecular Dynamics Simulations to Identify Rarely Sampled Ligand-bound Conformational States of Undecaprenyl Pyrophosphate Synthase, an Antibacterial Target
por: Sinko, William, et al.
Publicado: (2011) -
Farnesyl Diphosphate Synthase Inhibitors from In Silico Screening
por: Lindert, Steffen, et al.
Publicado: (2013) -
Species Differences in Alternative Substrate Utilization
by the Antibacterial Target Undecaprenyl Pyrophosphate Synthase
por: Dodbele, Samantha, et al.
Publicado: (2014) -
Biophysical Investigation of the Mode of Inhibition of Tetramic Acids, the Allosteric Inhibitors of Undecaprenyl Pyrophosphate Synthase
por: Lee, Lac V., et al.
Publicado: (2010) -
Anthranilic Acid Inhibitors of Undecaprenyl Pyrophosphate Synthase (UppS), an Essential Enzyme for Bacterial Cell Wall Biosynthesis
por: Jukič, Marko, et al.
Publicado: (2019)