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Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu(5))
[Image: see text] Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGlu(5)) represent a promising therapeutic strategy for the treatment of schizophrenia. Starting from an acetylene-based lead from high throughput screening, an evolved bicyclic dihydronaphthyridinone was i...
Autores principales: | Turlington, Mark, Malosh, Chrysa, Jacobs, Jon, Manka, Jason T., Noetzel, Meredith J., Vinson, Paige N., Jadhav, Satyawan, Herman, Elizabeth J., Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M., Conde-Ceide, Susana, Martín-Martín, M. Luz, Tong, Han Min, López, Silvia, MacDonald, Gregor J., Steckler, Thomas, Daniels, J. Scott, Weaver, C. David, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096224/ https://www.ncbi.nlm.nih.gov/pubmed/24914612 http://dx.doi.org/10.1021/jm500259z |
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