Improving the Power of GWAS and Avoiding Confounding from Population Stratification with PC-Select

Using a reduced subset of SNPs in a linear mixed model can improve power for genome-wide association studies, yet this can result in insufficient correction for population stratification. We propose a hybrid approach using principal components that does not inflate statistics in the presence of popu...

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Detalles Bibliográficos
Autores principales: Tucker, George, Price, Alkes L., Berger, Bonnie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2014
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096359/
https://www.ncbi.nlm.nih.gov/pubmed/24788602
http://dx.doi.org/10.1534/genetics.114.164285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096359/
https://www.ncbi.nlm.nih.gov/pubmed/24788602
http://dx.doi.org/10.1534/genetics.114.164285

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