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Improving the Power of GWAS and Avoiding Confounding from Population Stratification with PC-Select
Using a reduced subset of SNPs in a linear mixed model can improve power for genome-wide association studies, yet this can result in insufficient correction for population stratification. We propose a hybrid approach using principal components that does not inflate statistics in the presence of popu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Genetics Society of America
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096359/ https://www.ncbi.nlm.nih.gov/pubmed/24788602 http://dx.doi.org/10.1534/genetics.114.164285 |