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Fitness Is Strongly Influenced by Rare Mutations of Large Effect in a Microbial Mutation Accumulation Experiment

Our understanding of the evolutionary consequences of mutation relies heavily on estimates of the rate and fitness effect of spontaneous mutations generated by mutation accumulation (MA) experiments. We performed a classic MA experiment in which frequent sampling of MA lines was combined with whole...

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Detalles Bibliográficos
Autores principales:	Heilbron, Karl, Toll-Riera, Macarena, Kojadinovic, Mila, MacLean, R. Craig
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2014
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096375/ https://www.ncbi.nlm.nih.gov/pubmed/24814466 http://dx.doi.org/10.1534/genetics.114.163147

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