Interactions between HIV-1 and the Cell-Autonomous Innate Immune System

HIV-1 was recognized as the cause of AIDS in humans in 1984. Despite 30 years of intensive research, we are still unraveling the molecular details of the host-pathogen interactions that enable this virus to escape immune clearance and cause immunodeficiency. Here we explore a series of recent studie...

Descripción completa

Detalles Bibliográficos
Autores principales: Towers, Greg J., Noursadeghi, Mahdad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096382/
https://www.ncbi.nlm.nih.gov/pubmed/25011104
http://dx.doi.org/10.1016/j.chom.2014.06.009
Descripción
Sumario:HIV-1 was recognized as the cause of AIDS in humans in 1984. Despite 30 years of intensive research, we are still unraveling the molecular details of the host-pathogen interactions that enable this virus to escape immune clearance and cause immunodeficiency. Here we explore a series of recent studies that consider how HIV-1 interacts with the cell-autonomous innate immune system as it navigates its way in and out of host cells. We discuss how these studies improve our knowledge of HIV-1 and host biology as well as increase our understanding of transmission, persistence, and immunodeficiency and the potential for therapeutic or prophylactic interventions.

Ejemplares similares