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Epigenetic Inheritance, Epimutation, and the Response to Selection

There has been minimal theoretical exploration of the role of epigenetic variation in the response to natural selection. Using a population genetic model, I derive formulae that characterize the response of epigenetic variation to selection over multiple generations. Unlike genetic models in which m...

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Autor principal: Furrow, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096402/
https://www.ncbi.nlm.nih.gov/pubmed/25019291
http://dx.doi.org/10.1371/journal.pone.0101559
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author Furrow, Robert E.
author_facet Furrow, Robert E.
author_sort Furrow, Robert E.
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description There has been minimal theoretical exploration of the role of epigenetic variation in the response to natural selection. Using a population genetic model, I derive formulae that characterize the response of epigenetic variation to selection over multiple generations. Unlike genetic models in which mutation rates are assumed to be low relative to the strength of selection, the response to selection decays quickly due to a rapid lowering of parent-offspring epiallelic correlation. This effect is separate from the slowing response caused by a reduction in epigenetic variation. These results suggest that epigenetic variation may be less responsive to natural selection than is genetic variation, even in cases where levels of heritability appear similar.
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spelling pubmed-40964022014-07-17 Epigenetic Inheritance, Epimutation, and the Response to Selection Furrow, Robert E. PLoS One Research Article There has been minimal theoretical exploration of the role of epigenetic variation in the response to natural selection. Using a population genetic model, I derive formulae that characterize the response of epigenetic variation to selection over multiple generations. Unlike genetic models in which mutation rates are assumed to be low relative to the strength of selection, the response to selection decays quickly due to a rapid lowering of parent-offspring epiallelic correlation. This effect is separate from the slowing response caused by a reduction in epigenetic variation. These results suggest that epigenetic variation may be less responsive to natural selection than is genetic variation, even in cases where levels of heritability appear similar. Public Library of Science 2014-07-14 /pmc/articles/PMC4096402/ /pubmed/25019291 http://dx.doi.org/10.1371/journal.pone.0101559 Text en © 2014 Robert E http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Furrow, Robert E.
Epigenetic Inheritance, Epimutation, and the Response to Selection
title Epigenetic Inheritance, Epimutation, and the Response to Selection
title_full Epigenetic Inheritance, Epimutation, and the Response to Selection
title_fullStr Epigenetic Inheritance, Epimutation, and the Response to Selection
title_full_unstemmed Epigenetic Inheritance, Epimutation, and the Response to Selection
title_short Epigenetic Inheritance, Epimutation, and the Response to Selection
title_sort epigenetic inheritance, epimutation, and the response to selection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096402/
https://www.ncbi.nlm.nih.gov/pubmed/25019291
http://dx.doi.org/10.1371/journal.pone.0101559
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