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Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-ε-caprolactone nanofibers and growth factors for prevention of incisional hernia formation
Incisional hernia affects up to 20% of patients after abdominal surgery. Unlike other types of hernia, its prognosis is poor, and patients suffer from recurrence within 10 years of the operation. Currently used hernia-repair meshes do not guarantee success, but only extend the recurrence-free period...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096451/ https://www.ncbi.nlm.nih.gov/pubmed/25031534 http://dx.doi.org/10.2147/IJN.S63095 |
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author | Plencner, Martin East, Barbora Tonar, Zbyněk Otáhal, Martin Prosecká, Eva Rampichová, Michala Krejčí, Tomáš Litvinec, Andrej Buzgo, Matej Míčková, Andrea Nečas, Alois Hoch, Jiří Amler, Evžen |
author_facet | Plencner, Martin East, Barbora Tonar, Zbyněk Otáhal, Martin Prosecká, Eva Rampichová, Michala Krejčí, Tomáš Litvinec, Andrej Buzgo, Matej Míčková, Andrea Nečas, Alois Hoch, Jiří Amler, Evžen |
author_sort | Plencner, Martin |
collection | PubMed |
description | Incisional hernia affects up to 20% of patients after abdominal surgery. Unlike other types of hernia, its prognosis is poor, and patients suffer from recurrence within 10 years of the operation. Currently used hernia-repair meshes do not guarantee success, but only extend the recurrence-free period by about 5 years. Most of them are nonresorbable, and these implants can lead to many complications that are in some cases life-threatening. Electrospun nanofibers of various polymers have been used as tissue scaffolds and have been explored extensively in the last decade, due to their low cost and good biocompatibility. Their architecture mimics the natural extracellular matrix. We tested a biodegradable polyester poly-ε-caprolactone in the form of nanofibers as a scaffold for fascia healing in an abdominal closure-reinforcement model for prevention of incisional hernia formation. Both in vitro tests and an experiment on a rabbit model showed promising results. |
format | Online Article Text |
id | pubmed-4096451 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-40964512014-07-16 Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-ε-caprolactone nanofibers and growth factors for prevention of incisional hernia formation Plencner, Martin East, Barbora Tonar, Zbyněk Otáhal, Martin Prosecká, Eva Rampichová, Michala Krejčí, Tomáš Litvinec, Andrej Buzgo, Matej Míčková, Andrea Nečas, Alois Hoch, Jiří Amler, Evžen Int J Nanomedicine Original Research Incisional hernia affects up to 20% of patients after abdominal surgery. Unlike other types of hernia, its prognosis is poor, and patients suffer from recurrence within 10 years of the operation. Currently used hernia-repair meshes do not guarantee success, but only extend the recurrence-free period by about 5 years. Most of them are nonresorbable, and these implants can lead to many complications that are in some cases life-threatening. Electrospun nanofibers of various polymers have been used as tissue scaffolds and have been explored extensively in the last decade, due to their low cost and good biocompatibility. Their architecture mimics the natural extracellular matrix. We tested a biodegradable polyester poly-ε-caprolactone in the form of nanofibers as a scaffold for fascia healing in an abdominal closure-reinforcement model for prevention of incisional hernia formation. Both in vitro tests and an experiment on a rabbit model showed promising results. Dove Medical Press 2014-07-09 /pmc/articles/PMC4096451/ /pubmed/25031534 http://dx.doi.org/10.2147/IJN.S63095 Text en © 2014 Plencner et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Plencner, Martin East, Barbora Tonar, Zbyněk Otáhal, Martin Prosecká, Eva Rampichová, Michala Krejčí, Tomáš Litvinec, Andrej Buzgo, Matej Míčková, Andrea Nečas, Alois Hoch, Jiří Amler, Evžen Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-ε-caprolactone nanofibers and growth factors for prevention of incisional hernia formation |
title | Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-ε-caprolactone nanofibers and growth factors for prevention of incisional hernia formation |
title_full | Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-ε-caprolactone nanofibers and growth factors for prevention of incisional hernia formation |
title_fullStr | Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-ε-caprolactone nanofibers and growth factors for prevention of incisional hernia formation |
title_full_unstemmed | Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-ε-caprolactone nanofibers and growth factors for prevention of incisional hernia formation |
title_short | Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-ε-caprolactone nanofibers and growth factors for prevention of incisional hernia formation |
title_sort | abdominal closure reinforcement by using polypropylene mesh functionalized with poly-ε-caprolactone nanofibers and growth factors for prevention of incisional hernia formation |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096451/ https://www.ncbi.nlm.nih.gov/pubmed/25031534 http://dx.doi.org/10.2147/IJN.S63095 |
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