Cargando…

SUMOylation inhibits FOXM1 activity and delays mitotic transition

The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but not by SUMO2/3 at multiple sites. We show tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Myatt, S S, Kongsema, M, Man, C W-Y, Kelly, D J, Gomes, A R, Khongkow, P, Karunarathna, U, Zona, S, Langer, J K, Dunsby, C W, Coombes, R C, French, P M, Brosens, J J, Lam, E W-F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096495/ https://www.ncbi.nlm.nih.gov/pubmed/24362530 http://dx.doi.org/10.1038/onc.2013.546

Ejemplares similares

OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance
por: Karunarathna, U, et al.
Publicado: (2016)

FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance
por: Khongkow, Pasarat, et al.
Publicado: (2013)

Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance
por: Khongkow, P, et al.
Publicado: (2016)

RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment
por: Kongsema, M, et al.
Publicado: (2016)

FOXM1: An emerging master regulator of DNA damage response and genotoxic agent resistance
por: Zona, Stefania, et al.
Publicado: (2014)

The Anticancer Effects of FDI-6, a FOXM1 Inhibitor, on Triple Negative Breast Cancer
por: Ulhaka, Karan, et al.
Publicado: (2021)

Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance
por: Nestal de Moraes, Gabriela, et al.
Publicado: (2016)

Molecular mechanism of Forkhead box M1 inhibition by thiostrepton in breast cancer cells
por: Kongsema, Mesayamas, et al.
Publicado: (2019)

Phosphorylation-dependent mitotic SUMOylation drives nuclear envelope–chromatin interactions
por: Ptak, Christopher, et al.
Publicado: (2021)

FOXM1 repression increases mitotic death upon antimitotic chemotherapy through BMF upregulation
por: Vaz, Sara, et al.
Publicado: (2021)

FOXM1 is a transcriptional target of ERα and has a critical role in breast cancer endocrine sensitivity and resistance
por: Millour, Julie, et al.
Publicado: (2010)

Mitotic and Meiotic Functions for the SUMOylation Pathway in the Caenorhabditis elegans Germline
por: Reichman, Rachel, et al.
Publicado: (2018)

PICH regulates the abundance and localization of SUMOylated proteins on mitotic chromosomes
por: Hassebroek, Victoria A., et al.
Publicado: (2020)

The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment
por: Monteiro, Lara J., et al.
Publicado: (2012)

SUMOylation modulates FOXK2-mediated paclitaxel sensitivity in breast cancer cells
por: Nestal de Moraes, Gabriela, et al.
Publicado: (2018)

FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer
por: Karadedou, Christina T., et al.
Publicado: (2011)

FOXM1 modulates 5-fluorouracil sensitivity in cholangiocarcinoma through thymidylate synthase (TYMS): implications of FOXM1–TYMS axis uncoupling in 5-FU resistance
por: Intuyod, Kitti, et al.
Publicado: (2018)

Overexpression of Forkhead Box Protein M1 (FOXM1) in Ovarian Cancer Correlates with Poor Patient Survival and Contributes to Paclitaxel Resistance
por: Zhao, Fung, et al.
Publicado: (2014)

Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance
por: Gomes, Ana R., et al.
Publicado: (2013)

Retraction Note to: FOXM1 modulates 5-fluorouracil sensitivity in cholangiocarcinoma through thymidylate synthase (TYMS): implications of FOXM1–TYMS axis uncoupling in 5-FU resistance
por: Intuyod, Kitti, et al.
Publicado: (2021)

FOXM1 recruits nuclear Aurora kinase A to participate in a positive feedback loop essential for the self-renewal of breast cancer stem cells
por: Yang, N, et al.
Publicado: (2017)

Sumoylation of Kif18A plays a role in regulating mitotic progression
por: Yang, Feikun, et al.
Publicado: (2015)

FOXM1b, which is present at elevated levels in cancer cells, has a greater transforming potential than FOXM1c
por: Lam, Andy K. Y., et al.
Publicado: (2013)

A sumoylation program is essential for maintaining the mitotic fidelity in proliferating mantle cell lymphoma cells
por: Hanel, Walter, et al.
Publicado: (2022)

The clock protein period 2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells
por: Muter, Joanne, et al.
Publicado: (2015)

Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling
por: Kruiswijk, F, et al.
Publicado: (2016)

A novel FOXM1 isoform, FOXM1D, promotes epithelial–mesenchymal transition and metastasis through ROCKs activation in colorectal cancer
por: Zhang, X, et al.
Publicado: (2017)

Delayed expression of apoptosis in human lymphoma cells undergoing low-dose taxol-induced mitotic stress
por: Allman, R, et al.
Publicado: (2003)

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
por: Macedo, Joana Catarina, et al.
Publicado: (2018)

SUMOylation of FOXM1B Alters Its Transcriptional Activity on Regulation of MiR-200 Family and JNK1 in MCF7 Human Breast Cancer Cells
por: Wang, Chiung-Min, et al.
Publicado: (2014)

The role of karyopherins in the regulated sumoylation of septins
por: Makhnevych, Taras, et al.
Publicado: (2007)

Mapping the SUMOylated landscape
por: Eifler, Karolin, et al.
Publicado: (2015)

SUMOylation in Drosophila Development
por: Smith, Matthew, et al.
Publicado: (2012)

Homeostatic Synaptic Scaling Is Regulated by Protein SUMOylation
por: Craig, Tim J., et al.
Publicado: (2012)

FOXM1: Functional Roles of FOXM1 in Non-Malignant Diseases
por: Zhang, Zhenwang, et al.
Publicado: (2023)

SUMOylation of nuclear actin
por: Hofmann, Wilma A., et al.
Publicado: (2009)

RUNX family members are covalently modified and regulated by PIAS1-mediated sumoylation
por: Kim, J-H, et al.
Publicado: (2014)

Distinct Mitotic Functions of Nucleolar and Spindle-Associated Protein 1 (NuSAP1) Are Controlled by Two Consensus SUMOylation Sites
por: Damizia, Michela, et al.
Publicado: (2023)

Imaging of Metabolic Status in 3D Cultures with an Improved AMPK FRET Biosensor for FLIM
por: Chennell, George, et al.
Publicado: (2016)

Homo-FRET Based Biosensors and Their Application to Multiplexed Imaging of Signalling Events in Live Cells
por: Warren, Sean C., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_1bgtiktburaitfjkph8qd95ts6