Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a highly-abundant nuclear long noncoding RNA that promotes malignancy. A 3′-stem-loop structure is predicted to confer stability by engaging a downstream A-rich tract in a triple helix, similar to the expression and nuclear retention...

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Detalles Bibliográficos
Autores principales: Brown, Jessica A., Bulkley, David, Wang, Jimin, Valenstein, Max L., Yario, Therese A., Steitz, Thomas A., Steitz, Joan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096706/
https://www.ncbi.nlm.nih.gov/pubmed/24952594
http://dx.doi.org/10.1038/nsmb.2844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096706/
https://www.ncbi.nlm.nih.gov/pubmed/24952594
http://dx.doi.org/10.1038/nsmb.2844

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