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Sequential Administration of Carbon Nanotubes and Near-Infrared Radiation for the Treatment of Gliomas
The objective was to use carbon nanotubes (CNT) coupled with near-infrared radiation (NIR) to induce hyperthermia as a novel non-ionizing radiation treatment for primary brain tumors, glioblastoma multiforme (GBM). In this study, we report the therapeutic potential of hyperthermia-induced thermal ab...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097104/ https://www.ncbi.nlm.nih.gov/pubmed/25077069 http://dx.doi.org/10.3389/fonc.2014.00180 |
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author | Santos, Tiago Fang, Xin Chen, Meng-Tse Wang, Weijun Ferreira, Raquel Jhaveri, Niyati Gundersen, Martin Zhou, Chongwu Pagnini, Paul Hofman, Florence M. Chen, Thomas C. |
author_facet | Santos, Tiago Fang, Xin Chen, Meng-Tse Wang, Weijun Ferreira, Raquel Jhaveri, Niyati Gundersen, Martin Zhou, Chongwu Pagnini, Paul Hofman, Florence M. Chen, Thomas C. |
author_sort | Santos, Tiago |
collection | PubMed |
description | The objective was to use carbon nanotubes (CNT) coupled with near-infrared radiation (NIR) to induce hyperthermia as a novel non-ionizing radiation treatment for primary brain tumors, glioblastoma multiforme (GBM). In this study, we report the therapeutic potential of hyperthermia-induced thermal ablation using the sequential administration of carbon nanotubes (CNT) and NIR. In vitro studies were performed using glioma tumor cell lines (U251, U87, LN229, T98G). Glioma cells were incubated with CNTs for 24 h followed by exposure to NIR for 10 min. Glioma cells preferentially internalized CNTs, which upon NIR exposure, generated heat, causing necrotic cell death. There were minimal effects to normal cells, which correlate to their minimal uptake of CNTs. Furthermore, this protocol caused cell death to glioma cancer stem cells, and drug-resistant as well as drug-sensitive glioma cells. This sequential hyperthermia therapy was effective in vivo in the rodent tumor model resulting in tumor shrinkage and no recurrence after only one treatment. In conclusion, this sequence of selective CNT administration followed by NIR activation provides a new approach to the treatment of glioma, particularly drug-resistant gliomas. |
format | Online Article Text |
id | pubmed-4097104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-40971042014-07-30 Sequential Administration of Carbon Nanotubes and Near-Infrared Radiation for the Treatment of Gliomas Santos, Tiago Fang, Xin Chen, Meng-Tse Wang, Weijun Ferreira, Raquel Jhaveri, Niyati Gundersen, Martin Zhou, Chongwu Pagnini, Paul Hofman, Florence M. Chen, Thomas C. Front Oncol Oncology The objective was to use carbon nanotubes (CNT) coupled with near-infrared radiation (NIR) to induce hyperthermia as a novel non-ionizing radiation treatment for primary brain tumors, glioblastoma multiforme (GBM). In this study, we report the therapeutic potential of hyperthermia-induced thermal ablation using the sequential administration of carbon nanotubes (CNT) and NIR. In vitro studies were performed using glioma tumor cell lines (U251, U87, LN229, T98G). Glioma cells were incubated with CNTs for 24 h followed by exposure to NIR for 10 min. Glioma cells preferentially internalized CNTs, which upon NIR exposure, generated heat, causing necrotic cell death. There were minimal effects to normal cells, which correlate to their minimal uptake of CNTs. Furthermore, this protocol caused cell death to glioma cancer stem cells, and drug-resistant as well as drug-sensitive glioma cells. This sequential hyperthermia therapy was effective in vivo in the rodent tumor model resulting in tumor shrinkage and no recurrence after only one treatment. In conclusion, this sequence of selective CNT administration followed by NIR activation provides a new approach to the treatment of glioma, particularly drug-resistant gliomas. Frontiers Media S.A. 2014-07-15 /pmc/articles/PMC4097104/ /pubmed/25077069 http://dx.doi.org/10.3389/fonc.2014.00180 Text en Copyright © 2014 Santos, Fang, Chen, Wang, Ferreira, Jhaveri, Gundersen, Zhou, Pagnini, Hofman and Chen. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Santos, Tiago Fang, Xin Chen, Meng-Tse Wang, Weijun Ferreira, Raquel Jhaveri, Niyati Gundersen, Martin Zhou, Chongwu Pagnini, Paul Hofman, Florence M. Chen, Thomas C. Sequential Administration of Carbon Nanotubes and Near-Infrared Radiation for the Treatment of Gliomas |
title | Sequential Administration of Carbon Nanotubes and Near-Infrared Radiation for the Treatment of Gliomas |
title_full | Sequential Administration of Carbon Nanotubes and Near-Infrared Radiation for the Treatment of Gliomas |
title_fullStr | Sequential Administration of Carbon Nanotubes and Near-Infrared Radiation for the Treatment of Gliomas |
title_full_unstemmed | Sequential Administration of Carbon Nanotubes and Near-Infrared Radiation for the Treatment of Gliomas |
title_short | Sequential Administration of Carbon Nanotubes and Near-Infrared Radiation for the Treatment of Gliomas |
title_sort | sequential administration of carbon nanotubes and near-infrared radiation for the treatment of gliomas |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097104/ https://www.ncbi.nlm.nih.gov/pubmed/25077069 http://dx.doi.org/10.3389/fonc.2014.00180 |
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