Cognitive Impairment in CKD: Keep Vascular Disease in Mind: Commentary for Kidney International on ‘Cognitive impairment in chronic kidney disease: Prevalence, severity and association with HbA1c and fibrinogen’

Cognitive impairment is a major cause of morbidity in people with chronic kidney disease (CKD) and is associated with lower quality of life, more difficulty adhering to medications, and worse survival. Prior data suggest a relationship between vascular disease and cognitive impairment in individuals with CKD, although overall risk factors remain poorly understood. Critically, clinicians should be aware of the high rates of cognitive impairment that occur in all stages of CKD, which, although sometimes subtle, may impact comprehension and decision making in these individuals and may herald future, more debilitating impairment.